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Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1.

• Hilde Brems, Eline Beert, Thomy de Ravel, Eric Legius
• The Lancet. Oncology
• 2009

Neurofibromatosis type 1 (NF1) is a familial tumour syndrome. Malignant tumours can arise in the nervous and non-nervous system in either childhood or adulthood, with malignant peripheral nerve… (More)

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies.

• Thomas de Raedt, Eline Beert, +13 authors Karen Cichowski
• Nature
• 2014

The polycomb repressive complex 2 (PRC2) exerts oncogenic effects in many tumour types. However, loss-of-function mutations in PRC2 components occur in a subset of haematopoietic malignancies,… (More)

Glomus tumors in neurofibromatosis type 1: genetic, functional, and clinical evidence of a novel association.

• Hilde Brems, Caroline L. Park, +14 authors Douglas R. Stewart
• Cancer research
• 2009

Neurofibromatosis type 1 (NF1) is a common disorder that arises secondary to mutations in the tumor suppressor gene NF1. Glomus tumors are small, benign but painful tumors that originate from the… (More)

Legius Syndrome in Fourteen Families

• Ellen Denayer, Magdalena Chmara, +19 authors Eric Legius
• Human mutation
• 2011

Legius syndrome presents as an autosomal dominant condition characterized by café-au-lait macules with or without freckling and sometimes a Noonan-like appearance and/or learning difficulties. It is… (More)

Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors.

• Eline Beert, Hilde Brems, +13 authors Eric Legius
• Genes, chromosomes & cancer
• 2011

Benign peripheral nerve sheath tumors (PNSTs) are a characteristic feature of neurofibromatosis type I (NF1) patients. NF1 individuals have an 8-13% lifetime risk of developing a malignant PNST… (More)

Comparative Oncogenomic Analysis of Copy Number Alterations in Human and Zebrafish Tumors Enables Cancer Driver Discovery

• Guangjun Zhang, Sebastian Hoersch, +8 authors Jacqueline A. Lees
• PLoS genetics
• 2013

The identification of cancer drivers is a major goal of current cancer research. Finding driver genes within large chromosomal events is especially challenging because such alterations encompass many… (More)

EPCAM germline and somatic rearrangements in Lynch syndrome: identification of a novel 3'EPCAM deletion.

• Marijke Spaepen, Esther Neven, +6 authors Hilde Brems
• Genes, chromosomes & cancer
• 2013

3'EPCAM (Epithelial Cell Adhesion Molecule) genomic rearrangements can be a cause of mismatch repair deficiency in rare Lynch syndrome families. 3'EPCAM deletions include the polyadenylation signal… (More)

Bisulfite Sequencing with Daphnia Highlights a Role for Epigenetics in Regulating Stress Response to Microcystis through Preferential Differential Methylation of Serine and Threonine Amino Acids.

• Jana Asselman, Dieter I. M. De Coninck, +5 authors Karel Ac De Schamphelaere
• Environmental science & technology
• 2017

Little is known about the influence that environmental stressors may have on genome-wide methylation patterns, and to what extent epigenetics may be involved in environmental stress response. Yet,… (More)

Multiple orbital neurofibromas, painful peripheral nerve tumors, distinctive face and marfanoid habitus: a new syndrome

• Duscia Babovic-Vuksanovic, Ludwine Messiaen, +16 authors Eric Legius
• European Journal of Human Genetics
• 2012

Four unrelated patients having an unusual clinical phenotype, including multiple peripheral nerve sheath tumors, are reported. Their clinical features were not typical of any known familial tumor… (More)

Mitotic recombination of chromosome arm 17q as a cause of loss of heterozygosity of NF1 in neurofibromatosis type 1-associated glomus tumors.

• Douglas R. Stewart, Alexander Pemov, +8 authors Eric Legius
• Genes, chromosomes & cancer
• 2012

Neurofibromatosis type 1 (NF1) is a common, autosomal dominant, tumor-predisposition syndrome that arises secondary to mutations in NF1. Glomus tumors are painful benign tumors that originate from… (More)

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