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BACKGROUND The relationship between adolescent body mass index (BMI) and future risk for end-stage renal disease (ESRD) is not fully understood, nor is it known the extent to which this association is limited to diabetic ESRD. We evaluated the association between BMI in adolescence and the risk for all-cause, diabetic, and nondiabetic ESRD. METHODS(More)
CONTEXT Few data are available on long-term outcomes among adolescents and young adults with persistent asymptomatic isolated microscopic hematuria. OBJECTIVE To evaluate the risk of end-stage renal disease (ESRD) in adolescents and young adults with persistent asymptomatic isolated microscopic hematuria. DESIGN, SETTING, AND PARTICIPANTS Nationwide,(More)
High blood and tissue concentrations of glucose and advanced glycation end products (AGEs) are thought to play an important role in the development of diabetic vascular complications. Thioredoxin interacting protein (TXNIP) is up-regulated in response to high levels of glucose and is an endogenous inhibitor of thioredoxin (TRX), and may play a contributory(More)
Advanced glycation end products (AGEs), which are elevated in diabetic and uremic patients, may induce vascular dysfunctions, and calcitriol may improve the cardiovascular complications. Therefore, we examined whether calcitriol may modify the endothelial response to AGEs stimulation. Knowing the importance of nuclear factor-kappaB in endothelial(More)
BACKGROUND AND OBJECTIVES Pain is a frequent complaint of hemodialysis (HD) patients, yet information regarding its causes and frequency is relatively scarce. The aim of this study was to evaluate the frequency and possible causes of chronic pain in patients who are on long-term HD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS We prospectively enrolled(More)
BACKGROUND Current blood pressure (BP) classification is based on the recent recommendations of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC-7) and the 2003 European Society of Hypertension-European Society of Cardiology Guidelines for the Management of Arterial Hypertension. The JNC-7(More)
UNLABELLED Nonsteroidal antiinflammatory drugs (NSAIDs) have become increasingly popular in the treatment of perioperative pain. Due to concerns that cyclooxygenase inhibition may adversely affect renal function, these drugs are often not used in geriatric surgical patients. However, the perioperative effect of NSAIDs on renal blood flow (RBF) and(More)
Exposure of the major salivary glands to ionizing radiation often results in severe alterations in structure and function. The mechanism of these effects is still unknown, and no adequate prevention or treatment is yet available. The purpose of this study was to examine a mechanism based on the assumption that redox-active metal ions, which propagate the(More)
Between 1975 and 1979, 511 injuries were caused by "terrorist" explosions in Jerusalem; 340 patients were treated at the Shaare Zedek Medical Center. The injuries were studied and analyzed. The Department of Plastic Surgery bore the brunt of the work, receiving over one-third of all admissions. More than half the hospitalization days went to plastic surgery(More)
During a period of 4 1/2 yr, 24 terrorist explosions occurred in Jerusalem. Of the 511 casualties, 340 were evacuated to the Department of Emergency in our hospital. A total of 272 admissions were graded by the "Injury Severity Score" (1), with a breakdown into light injuries (87%), medium (3%) and severe (10%). The high proportion of light injuries may be(More)