Elias H. Botvinick

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Patient motion during image acquisition is a frequent cause of SPECT perfusion image artifacts. We sought to determine the relationship between patient motion and the resultant image artifact. The effect of patient motion on 201Tl SPECT scintigrams was assessed with computer simulation to create 66 new image sets with artifactual vertical, horizontal and(More)
UNLABELLED Myocardial perfusion imaging with SPECT remains critically important for diagnosing, assessing, and evaluating treatment of coronary artery disease. However, conventional rotational SPECT suffers from prolonged study times because of relatively low detection efficiency. We therefore have investigated a multipinhole collimator that could improve(More)
Planar equilibrium radionuclide angiography (ERNA) is used to determine global and regional measures of ventricular function (primarily left ventricular [LV] function) at rest and/or during exercise stress or pharma-cologic intervention. These measures of ventricular function may include evaluations of ventricular wall motion, ejection fraction (EF), and(More)
SUMMARY The usefulness of exercise electrocardiography (ECG) and myocardial stress perfusion scin-tigraphy (SPS) in the noninvasive identification of patients with left main or three-vessel coronary artery disease (CAD) was assessed. Ninety-six patients with chest pain were divided into three groups. Group I consisted of 44 patients with left main or(More)
—We developed fully 4-D penalized least-squares reconstruction methods that use overlapping multiresolution B-splines to represent radiopharmaceutical distributions that vary smoothly in space and time in human dynamic cardiac SPECT images. This approach does not require segmentation, and improves signal-to-noise and increases computational efficiency(More)
BACKGROUND Phase imaging derived from equilibrium radionuclide angiography presents the ventricular contraction sequence. It has been widely but only indirectly correlated with the sequence of electrical myocardial activation. OBJECTIVES We sought to determine the specific relationship between the sequence of phase progression and the sequence of(More)
See related article, pp. 895–903 There are 550,000 new cases of heart failure with 1,000,000 hospitalizations and 250,000 heart failure deaths yearly in the USA with similar numbers in the European Union. Cardiac resynchronization therapy (CRT), based in the placement of A-V sequential, biventricular pacemakers, is indicated to treat patients with advanced,(More)
BACKGROUND The pacing site has been shown to influence functional improvement with cardiac resynchronization therapy. We evaluated the effects of the pacing site on left ventricular (LV) function in an animal model. METHODS AND RESULTS Equilibrium radionuclide angiography was acquired in sinus rhythm (NSR) and with ventricular pacing, from three pacing(More)
To establish cardiac MRI as a tool for noninvasive evaluation of activation patterns, 10 healthy volunteers were examined by cine segmented turboFLASH imaging sequences. Sequence modifications for low signal blood-pool appearance were applied, i.e., bilateral spatial saturation for segmented turboFLASH imaging. Pixelwise calculation of first-harmonic(More)
Previous studies have noted that myocardial blood flow and high energy phosphates are heterogeneous across the myocardial wall during ischemia. In order to determine whether differences in metabolites between the subendocardium and subepicardium could be detected using 31P magnetic resonance spectroscopy, the Fourier series window (FSW) experiment was(More)
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