Elias Fares

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This study compared Ca(2+) homeostasis in ventricular myocytes from 8-month-old female C57BL/6J mice that had either a bilateral ovariectomy (OVX) or a sham surgery at 3 weeks of age. Cells were loaded with fura-2 and field-stimulated or voltage-clamped with steps to membrane potentials between -40 and +80 mV (37°C). Peak Ca(2+) transients increased by(More)
This study developed an approach to quantify frailty with a frailty index (FI) and investigated whether age-related changes in contractions, calcium transients, and ventricular myocyte length were more prominent in mice with a high FI. The FI combined 31 variables that reflect different aspects of health in middle-aged (∼12 months) and aged (∼30 months)(More)
1. Cardiovascular diseases most commonly occur in the elderly and are a frequent cause of disability or death. However, the effect of age itself on cardiac function is not well understood. 2. Studies in both human and animal hearts indicate that contractile function is unaffected by age while at rest. However, the ability to increase cardiac contractile(More)
This study determined whether deficiency of ovarian estrogen starting very early in life promoted age-associated Ca(2+) dysregulation and contractile dysfunction in isolated ventricular myocytes. Myocytes were isolated from anesthetized C57BL/6 female mice. Animals received an ovariectomy or sham-operation at one month and were aged to ~24 months.(More)
Phishing is a significant type of internet crime that tricks users into giving up their personal and financial information. To combat phishing, browser manufacturers, software vendors, and organizations have compiled repositories of phishing URLs (blacklists). These lists enable the analysis of reported phishing attacks to be shared among antiphishing(More)
Bend gestures can be used as a form of Around Device Interaction to address usability issues in touchscreen mobile devices. Yet, it is unclear whether bend gestures can be easily learned and memorized as control schema for games. To answer this, we built a novel deformable smartphone case that detects bend gestures at its corners and sides, and created(More)
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