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Engineering of a functional bone organ through endochondral ossification
Embryonic development, lengthening, and repair of most bones proceed by endochondral ossification, namely through formation of a cartilage intermediate. It was previously demonstrated that adultExpand
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Toward modeling the bone marrow niche using scaffold-based 3D culture systems.
In the bone marrow, specialized microenvironments, called niches, regulate hematopoietic stem cell (HSC) maintenance and function through a complex crosstalk between different cell types. Although inExpand
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Expansion of Human Mesenchymal Stromal Cells from Fresh Bone Marrow in a 3D Scaffold-Based System under Direct Perfusion
Mesenchymal stromal/stem cell (MSC) expansion in conventional monolayer culture on plastic dishes (2D) leads to progressive loss of functionality and thus challenges fundamental studies on theExpand
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Engineering a humanized bone organ model in mice to study bone metastases
Current in vivo models for investigating human primary bone tumors and cancer metastasis to the bone rely on the injection of human cancer cells into the mouse skeleton. This approach does not mimicExpand
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High-throughput micropatterning platform reveals Nodal-dependent bisection of peri-gastrulation–associated versus preneurulation-associated fate patterning
In vitro models of postimplantation human development are valuable to the fields of regenerative medicine and developmental biology. Here, we report characterization of a robust in vitro platformExpand
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In Memoriam: Paolo Bianco
The community of scientists, politicians, and regulators around the field of stem cell biology has been shocked by the sudden death of Paolo Bianco and by the loss of a passionate, rigorous, deeplyExpand
Human mesenchymal stromal cell expansion in a 3D scaffold-based system under direct perfusion
Development of systems allowing the maintenance of native properties of mesenchymal stromal cells (MSC) is a critical challenge for studying physiological functions of skeletal progenitors, as wellExpand
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ENGINEERING OF FUNCTIONAL ENDOCHONDRAL BONE AND HAEMATOPOIETIC MICROENVIRONMENT WITH HUMAN ADULT MESENCHYMAL STROMAL CELLS
Summary Statement This study reports that hMSC can be manipulated in order to engineer a bone organ, characterised by mature osseous and vascular components and capable to recruit, host and maintainExpand