Eli Shulman

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There is compelling evidence that aminoglycoside (AG) antibiotics can induce the mammalian ribosome to suppress disease-causing nonsense mutations and partially restore the expression of functional proteins. However, prolonged AG treatment can cause detrimental side effects in patients, including most prominently, ototoxicity. Recent mechanistic discussions(More)
Compelling evidence is now available that gentamicin and Geneticin (G418) can induce the mammalian ribosome to suppress disease-causing nonsense mutations and partially restore the expression of functional proteins. However, toxicity and relative lack of efficacy at subtoxic doses limit the use of gentamicin for suppression therapy. Although G418 exhibits(More)
The redox potentials for the Ru(IV)/Ru(III) and the Ru(III)/ Ru(I1) couples of complex 1 display potential shifts of 59 mV per pH unit, consistent with one-electron, one-proton transfers. In further cyclic voltammetric studies, when benzyl alcohol was added to an aqueous solution of the [(bpy)2Ru(IV)(0)(PEt3)]2+ complex, the electrochemical potential for(More)
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