Eli Nazarov

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Several papers have indicated the participation of cyclic AMP as a second messenger for the release of neurohypophysial hormones. Since very little is known about the effects of stress and drugs of abuse on this process, we studied the activity of adenylyl cyclase in the neurohypophyses after immobilization stress and chronic amphetamine treatment. Our(More)
Evaluating interface usability and system functionality is time-consuming and effort-intense. The short time-span involved in development iterations, such as those in agile development, makes it challenging for software teams to perform ongoing interface usability evaluation and system functionality testing. We propose a way to perform <i>product ongoing(More)
The new psychotropic drug phenazepam inhibits spike discharges of neurons composing the visceral ganglion of the garden snailHelix aspersa and depresses excitatory postsynaptic potentials arising in response to application of acetylcholine to the membrane of the isolated neuron. The parameters of the electrically excitable membrane remain basically(More)
The effect of polymethylene- and polyoxyethylene-bis-(2-amino-1, 3-diazepinium) iodides on the membranes of neuromuscular synapsis and mitochondria as on the artificial membranes was studied. The compounds examined were shown to change the amplitude and kinetics of postsynaptic membrane responses to acetylcholine. Inhibition of end plate potentials and(More)
The macrocyclic polyether 15-crown-5 at a concentration of 5 . 10(-5)-10(-3) M reduced the frequency of the contractions of an isolated rat auricle, increasing the refractory period of the contractions. The polyether lowered the rate of activation of the slow input current of rat spinal ganglionic neurons and blocked the sodium channels of the(More)
The effects of the local anesthetic pyromecaine on the action potential parameters of the guinea-pig heart ventricular cardiomyocytes as well as on Na and K ionic currents of the neurons in the rat spinal ganglions have been studied. Pyromecaine was shown to reduce preferentially the first derivative of the ascending phase of cardiomyocyte action potential(More)
A comparative analysis of new macrocyclic amidoesters effect on the bimolecular lipid membrane as well as on the electroexcitable membrane of snail isolated neurons was carried out. It was shown that the investigated complexes inducing a small change in lipid bilayer conductivity and some changes in Na-Ca neuron current characteristics produce essential(More)