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Developmental DNA methyltransferase inhibitors in the treatment of gynecologic cancers.

• Alfonso Dueñas-González, José Lius Medina-Franco, Alma D Chávez-Blanco, Guadalupe Domínguez-Gómez, Eli Fernández-de Gortari
• Expert opinion on pharmacotherapy
• 2016

INTRODUCTION DNA methylation has become an attractive target for the treatment of cancer. DNA methyltransferase inhibitors have proven useful for the treatment of myelodysplastic syndrome and are… (More)

Design and synthesis of N-benzoyl amino acid derivatives as DNA methylation inhibitors.

• Davide Garella, Sandra Atlante, +11 authors Massimo Bertinaria
• Chemical biology & drug design
• 2016

The inhibition of human DNA Methyl Transferases (DNMT) is a novel promising approach to address the epigenetic dysregulation of gene expression in different diseases. Inspired by the validated… (More)

Molecular Modeling and Chemoinformatics to Advance the Development of Modulators of Epigenetic Targets: A Focus on DNA Methyltransferases.

• Fernando D. Prieto-Martínez, A Peña-Castillo, Oscar Méndez-Lucio, Eli Fernández-de Gortari, José Luis Medina-Franco
• Advances in protein chemistry and structural…
• 2016

In light of the emerging field of Epi-informatics, ie, computational methods applied to epigenetic research, molecular docking, and dynamics, pharmacophore and activity landscape modeling and QSAR… (More)

Preexisting domain motions underlie protonation-dependent structural transitions of the P-type Ca2+-ATPase.

• Eli Fernández-de Gortari, L Michel Espinoza-Fonseca
• Physical chemistry chemical physics : PCCP
• 2017

We have performed microsecond molecular dynamics (MD) simulations to determine the mechanism for protonation-dependent structural transitions of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA),… (More)

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