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  • Marc Foretz, Sophie Hébrard, +6 authors Benoit Viollet
  • Medicine, Biology
  • The Journal of clinical investigation
  • 2010 (First Publication: 1 July 2010)
  • Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the action of metforminContinue Reading
  • Kei Sakamoto, Elham Zarrinpashneh, +8 authors Luc Bertrand
  • Medicine, Biology
  • American journal of physiology. Endocrinology and…
  • 2006 (First Publication: 1 May 2006)
  • Recent studies indicate that the LKB1 is a key regulator of the AMP-activated protein kinase (AMPK), which plays a crucial role in protecting cardiac muscle from damage during ischemia. We haveContinue Reading
  • Daphna D. J. Habets, Will A. Coumans, +9 authors Joost J.F.P. Luiken
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 2009 (First Publication: 1 March 2009)
  • Enhanced contractile activity increases cardiac long-chain fatty acid (LCFA) uptake via translocation of CD36 to the sarcolemma, similarly to increase in glucose uptake via GLUT4 translocation.Continue Reading
  • Karla Carvajal, Elham Zarrinpashneh, +10 authors Jacqueline A. Hoerter
  • Biology, Medicine
  • American journal of physiology. Heart and…
  • 2007 (First Publication: 1 June 2007)
  • Because the question "is AMP-activated protein kinase (AMPK) alpha(2)-isoform a friend or a foe in the protection of the myocardium against ischemia-reperfusion injury?" is still in debate, weContinue Reading
  • Elham Zarrinpashneh, Karla Carjaval, +10 authors Luc Bertrand
  • Biology, Medicine
  • American journal of physiology. Heart and…
  • 2006 (First Publication: 1 December 2006)
  • AMP-activated protein kinase (AMPK) is a major sensor and regulator of the energetic state of the cell. Little is known about the specific role of AMPKalpha(2), the major AMPK isoform in the heart,Continue Reading
  • Sébastien Jacquet, Elham Zarrinpashneh, +6 authors Michael Marber
  • Biology, Medicine
  • Cardiovascular research
  • 2007 (First Publication: 1 December 2007)
  • OBJECTIVE p38 mitogen-activated protein kinase (p38 MAPK) and AMP-activated protein kinase (AMPK) are activated by, and influence sensitivity to, myocardial ischemia. Recently a number of studiesContinue Reading