Eleri Thomas

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This study identifies type I IFNs as activating cytokines in a serum-free system in which human dendritic cells (DC) were generated from CD34+ progenitor cells. After 14 days of culture in GM-CSF, TNF-alpha, and IL-4, CD34+ progenitors gave rise to a population of large, immature DC expressing CD1a and CD11b but lacking CD14, CD80, CD83, CD86, and CMRF44.(More)
An 8-year-old boy with perinatal HIV infection developed a large fusiform aneurysm in the circle of Willis two years prior to death which was confirmed by radiological studies. The postmortem examinations revealed a predominantly intimal, proliferative lesion, and partial destruction of the internal elastic lamina in the involved arteries. Within the intima(More)
E n z y m e his tochemistry provides the possibility of differentiating morphologically well known tissues th rough quali tat ive and quant i ta t ive aspects of their metabolism. I n the central nervous system his to topoehemist ry has demonst ra ted a number of interesting facts. W o r t h y of fur ther s tudy are the regional changes of enzyme act iv i(More)
Using the monotetrazolium salt MTT, with Nitro-BT for control and comparison, the following enzyme systems were studied in the central and peripheral nervous system: DPNH and TPNH diaphorases (tetrazolium reductases), lactate, isocitrate, succinate, malate, β-hydroxybutyrate, glucose-6-phosphate and (mitochondrial) α-glycerophosphate dehydrogenases. In(More)
Mice previously latently infected with the F strain of herpes simplex virus type 1 (HSV-1) can be successfully colonized with a second virus strain if HSV-2 is introduced at the same peripheral site as HSV-1. On the other hand, HSV-1 strains seemed able mutually to exclude establishment of latency with each other. Mice (3 months or 3 years after nasal(More)
The antigen-presenting capacity of dendritic cells (DCs) makes them attractive potential cellular adjuvants for vaccination strategies. Currently, most in vitro culture systems for the production of these DCs include serum. However, this is undesirable because serum contains growth factors that vary between individuals and could affect DC development.(More)
We have recently shown that CD30, a member of the tumor necrosis factor/nerve growth factor receptor superfamily, is preferentially expressed by human T cell clones producing T helper (Th) type 2 cytokines. We report here that costimulation with an agonistic anti-CD30 monoclonal antibody enhanced antigen (Ag)-induced proliferation and cytokine secretion by(More)
This study was conducted to determine whether the atypical opioid analgesic tramadol inhibits the contractility of isolated non-pregnant human myometrium. Ten strips of non-pregnant human myometrium stimulated with 55 mm potassium chloride (KCl) were treated with three concentrations (30, 100 and 300 μm) of tramadol to test for any inhibitory effect of(More)
Enzyme activity of adenosinetriphosphatase, NADH2-tetrazolium reductase and lactate dehydrogenase was studied in the rat perineurium 10, 20, 30, and 90 days post partum. The effect of undernutrition was shown by a lack of enzyme activity in rats 30 days post partum in contrast to control animals. 30 days also corresponds to the time when, in normal rats,(More)