Eleonore Faber

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A number of cationic amine drugs that are taken up by liver and excreted into bile may accumulate in acidified intracellular organelles such as lysosomes and endosomes. These studies were undertaken to assess directly the uptake and accumulation of three types of model organic cationic amines by endocytic vesicles, and the role of vesicle acidification in(More)
We generalize the Chern class relation for the transversal intersection of two nonsingular varieties to a relation for possibly singular varieties, under a splayedness assumption. The relation is shown to hold for both the Chern– Schwartz–MacPherson class and the Chern–Fulton class. The main tool is a formula for Segre classes of splayed subschemes. We also(More)
We studied the pharmacokinetics of two synthetic derivatives of 1-deoxynojirimycin in the rat after intravenous administration. The mannosidase IA/B inhibitor 1-deoxymannojirimycin and the glucosidase inhibitor N-methyl-1-deoxynojirimycin exhibited minimal plasma protein binding and showed a rapid biphasic plasma disappearance, with an initial t1/2 of 3.0(More)
We obtain several new characterizations of splayedness for divisors: a Leibniz property for ideals of singularity subschemes, the vanishing of a 'splayed-ness' module, and the requirements that certain natural morphisms of modules and sheaves of logarithmic derivations and logarithmic differentials be isomorphisms. We also consider the effect of splayedness(More)
The hepatic disposition of two glycosidase inhibitors was studied in the isolated perfused rat liver and after subcellular fractionation. The mannosidase inhibitor 1-deoxymannojirimycin (dMM) and the glucosidase inhibitor N-methyl-1-deoxynojirimycin (MedNM) exhibited minimal binding to albumin and reached liver concentrations that approximately equaled(More)
In this paper we study endomorphism rings of finite global dimension over not necessarily normal commutative rings. These objects have recently attracted attention as noncommutative (crepant) resolutions (NC(C)Rs) of singularities. Our results yield various necessary and sufficient conditions for their existence. We also introduce and study the global(More)
The pharmacokinetic behavior of the glucosidase inhibitor and antiviral compound JV-benzyl-1-deoxynojirimycin (BndNM) was studied in rats in vivo and in isolated perfused livers. BndNM is a more lipophilic derivative of the glucosidase inhibitor A'-methyl-1-deoxynojirimycin (MedNM). This was reflected in the n-octanol/Krebs partition coefficients, which(More)
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