Eleonora Li Causi

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CD4+ T helper memory (Thmem) cells influence both natural and vaccine-boosted immunity, but mechanisms for their maintenance remain unclear. Pro-survival signals from the common gamma-chain cytokines, in particular IL-7, appear important. Previously we showed in healthy volunteers that a booster vaccination with tetanus toxoid (TT) expanded peripheral blood(More)
PURPOSE Gemcitabine, a nucleoside analogue, is an important treatment for locally advanced and metastatic pancreatic ductal adenocarcinoma (PDAC) but provides only modest survival benefit. Targeting downstream effectors of the RAS/ERK signaling pathway by direct inhibition of MEK1/2 proteins is a promising therapeutic strategy, as aberrant activation of(More)
Purpose: Gemcitabine, a nucleoside analogue, is an important treatment for locally advanced and metastatic pancreatic ductal adenocarcinoma(PDAC)butprovidesonlymodest survivalbenefit. Targeting downstream effectors of the RAS/ERK signaling pathway by direct inhibition of MEK1/2 proteins is a promising therapeutic strategy, as aberrant activation of this(More)
THE MEK1/2 INHIBITOR PIMASERTIB ENHANCES GEMCITABINE EFFICACY IN PANCREATIC CANCER MODELS BY ALTERING PROTEIN LEVELS OF RIBONUCLEOTIDE REDUCTASE SUBUNIT-1 (RRM1) Francesca Vena, Eleonora Li Causi, Manuel Rodriguez-Justo, Samantha Goodstal, Thorsten Hagemann, John A. Hartley and Daniel Hochhauser Cancer Research UK Drug-DNA Interactions Research Group, UCL(More)
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