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Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas
Analysis of DNA from saliva and plasma of 93 HNSCC patients found preliminary evidence suggesting that tumor DNA may be detectable in saliva before clinical evidence of tumor recurrence, which may be useful for patient monitoring if this result is confirmed in larger studies. Expand
The prognostic role of sex, race, and human papillomavirus in oropharyngeal and nonoropharyngeal head and neck squamous cell cancer
Survival differences were explored by the tumor HPV status among patients with OPSCCs by sex and race and patients with nonoropharyngeal (non‐OP) head and neck squamous cell cancers (HNSCCs). Expand
The role of sexual behavior in head and neck cancer: implications for prevention and therapy
Investigation should focus on elucidating the natural history of oral HPV infection persistence and malignant transformation, developing effective screening tools and exploring opportunities for prevention such as vaccination and public health education. Expand
Cleaved NOTCH1 Expression Pattern in Head and Neck Squamous Cell Carcinoma Is Associated with NOTCH1 Mutation, HPV Status, and High-Risk Features
NICD1 is expressed in three distinct patterns in HNSCC that are significantly associated with high-risk features and further support a dual role for NOTCH1 as both tumor suppressor and oncogene in H NSCC. Expand
Changes in Unknown Primary Squamous Cell Carcinoma of the Head and Neck at Initial Presentation in the Era of Human Papillomavirus.
The frequency of UPSCC has increased significantly in recent calendar periods, and most cases are HPV-positive, as expected, patients with HPV- positive UPSCC tend to be male and younger. Expand
MYB rearrangement and clinicopathologic characteristics in head and neck adenoid cystic carcinoma
The purposes of this study were to describe the clinicopathologic factors impacting survival and to determine the prevalence and clinical significance of MYB‐NFIB fusion. Expand
Health‐related quality of life before and after head and neck squamous cell carcinoma: Analysis of the Surveillance, Epidemiology, and End Results–Medicare Health Outcomes Survey linkage
Health‐related quality of life (HRQOL) is crucial to providing high‐quality survivorship care for patients with head and neck squamous cell carcinoma (HNSCC). Expand
Prognostic Implication of Persistent Human Papillomavirus Type 16 DNA Detection in Oral Rinses for Human Papillomavirus-Related Oropharyngeal Carcinoma.
The data suggest that, although infrequent, persistent HPV16 DNA in posttreatment oral rinses is associated with poor prognosis and is a potential tool for long-term tumor surveillance, perhaps more so for local recurrence. Expand
Increasing prevalence of human papillomavirus–positive oropharyngeal cancers among older adults
The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is increasing among older adults. It is unknown whether these trends can be explained by human papillomavirus (HPV) and whetherExpand
Rising population of survivors of oral squamous cell cancer in the United States
The incidence of oropharyngeal cancer and a subset of oral cavity cancer is increasing in the United States and the presumed growing prevalence of survivors of OPC and OCC has not been investigated to date. Expand