Eleni G. Christodoulou

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Chromatin immunoprecipitation coupled with deep sequencing (ChIP-seq) has great potential for elucidating transcriptional networks, by measuring genome-wide binding of transcription factors (TFs) at high resolution. Despite the precision of these experiments, identification of genes directly regulated by a TF (target genes) is not trivial. Numerous target(More)
Cohesin subunit SMC1β is specific and essential for meiosis. Previous studies showed functions of SMC1β in determining the axis-loop structure of synaptonemal complexes (SCs), in providing sister chromatid cohesion (SCC) in metaphase I and thereafter, in protecting telomere structure, and in synapsis. However, several central questions remained unanswered(More)
The aim of this study is to identify a gene signature which is characteristic of ER status in breast cancer patients. To our knowledge, this is the first microarray study in Greece concerning breast cancer. We identified 97 genes that are characteristic for ER status and can well distinguish the ER+ from the ERsamples. We also managed to shrink our list to(More)
Portal Catalogs is a popular means of searching for information on the Web. They provide querying and browsing capabilities on data organized in a hierarchy, on a category/subcategory basis. This paper presents mining techniques on user navigational patterns in the hierarchies of portal catalogs. Specifically, we study and implement navigation retrieval(More)
This paper presents BrainNetVis, a tool which serves brain network modelling and visualization, by providing both quantitative and qualitative network measures of brain interconnectivity. It emphasizes the needs that led to the creation of this tool by presenting similar works in the field and by describing how our tool contributes to the existing scenery.(More)
The chemosensitivity of tumours to specific drugs can be predicted based on molecular quantities, such as gene expressions, miRNA expressions, and protein concentrations. This finding is important for improving drug efficacy and personalizing drug use. In this paper, the authors present an analysis strategy that, compared to prior work, retains more(More)
Mutated KRAS plays an important role in many cancers. Although targeting KRAS directly is difficult, indirect inactivation via synthetic lethal partners (SLPs) is promising. Yet to date, there are no SLPs from high-throughput RNAi screening, which are supported by multiple screens. Here, we address this problem by aggregating and ranking data over three(More)
Prior work has shown that the sensitivity of a tumour to a specific drug can be predicted from a molecular signature of gene expressions. This is an important finding for improving drug efficacy and personalizing drug use. In this paper, we present an analysis strategy that, compared to prior work, maintains more information and leads to improved(More)
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