Elene I Adamskaya

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This study was aimed to test our hypothesis that, in contrast to adult rats, in fetuses and neonates, a large amount of the brain-derived GnRH is delivered to the general circulation. The GnRH concentration and content were estimated in general circulation and in the forebrain in rats on the 18th embryonic day (E18), E21, 3rd postnatal day (P3) and P30-36.(More)
1. Development of experimental diabetes in male rats is associated with reductions in the blood T concentration and in the number of nuclear androgen receptors in the adenohydraphysis. Blood LH and FSH levels did not change. 2. The LH-RH sensitivity of the hypophysis in STZ-treated male rats decreased sharply on incubation for more than 1h. 3.(More)
1. A decrease in the level of activity of both motivational and copulatory components of sexual behavior was observed during the development of experimental diabetes following the administration of streptozotocin to rat males. 2. The concentration of LHRH in diabetic rats decreased in the ME [sic], and similar changes were recorded in both the PA and the(More)
1. The amplitude of the circadian fluctuations of the level of NE, DA, and 5-HT in the hypothalamus of female rats depends on the phase of the estrous cycle: the most pronounced deviations from the circadian rhythm were observed in the preovulatory period in the anterior and mediobasal divisions of the hypothalamus. 2. All three investigated monoamines(More)
1. Injection of serotonin into the mediobasal hypothalamus inhibits LH secretion in phase P. An analogous effect with serotonin injection into the PO region is seen only in the initial period of this stage. 2. Injection of serotonin into the PO region of OE rats does not alter blood concentration of LH, while injection into the mediobasal region results in(More)
1. The administration of a blocker of a-adrenoreceptors does not influence the blood content of LH and FSH in the early hours of the E stage. 2. The administration of a blocker of DA (haloperidol) decreased, while a stimulator of the action (parlodel) increased the concentration of FSH in the blood at the 1 and 3 h stages of E without changes in the blood(More)
chemical nature of this phenomenon is not yet clear. It may be associated also with inhibition of enzymes which inactivate hydrocortisone and with an increase in binding of the hormone through slowing of catabolism of specific protein receptors in the thymocytes. Coincidence of the peak of the cortisone-like action of OT with the maximum of hypovitaminosis(More)
1. Administration of phentolamine (α-adrenoblocker) decreases the LH level in the blood of male rats. Administration against this background of mezatone (α-adrenostimulator) or apomorphine (DA stimulator) reverses the effect of phentolamine. 2. On administration into the PA or ARC, NA stimulates the release of gonadotropins from the adenohypophysis, by(More)
It is known that the disturbance in the functional activity of the reproductive system of the organism in diabetic laboratory animals is associated not only with destructive changes in the gonads, but with dysfunction of the hypothalamo-hypophyseal complex as well [11, 12]. It has been demonstrated that the decrease in the basal secretion of gonadotropins(More)
The contents of dopamine, serotonin, and noradrenaline in rat fetuses developing under the conditions of their deficiency induced by administration of α-methyl-para-tyrosine to females during 11th to 16th or 20th day of pregnancy and in fetuses, whose mothers were given saline at the same time, were determined using HPLC with subsequent electrochemical(More)