Elena Taran

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The glycine receptor is an anion-permeable member of the Cys-loop ion channel receptor family. Synaptic glycine receptors predominantly comprise pentameric α1β subunit heteromers. To date, attempts to define the subunit stoichiometry and arrangement of these receptors have not yielded consistent results. Here we introduced FLAG and six-His epitopes into α1(More)
BACKGROUND Nucleic acids based therapeutic approaches have gained significant interest in recent years towards the development of therapeutics against many diseases. Recently, research on aptamers led to the marketing of Macugen®, an inhibitor of vascular endothelial growth factor (VEGF) for the treatment of age related macular degeneration (AMD). Aptamer(More)
The adhesion of acidophilic bacteria to mineral surfaces is an important phenomenon in bioleaching processes. In this study, functionalized colloidal probes covered by bioleaching bacterial cells (Acidithiobacillus thiooxidans and Leptospirillum ferrooxidans) were developed and used to sense specific adhesion forces to a silica surface and a pyrite surface(More)
The role of curli expression in attachment of Escherichia coli O157:H7 to glass, Teflon, and stainless steel (SS) was investigated through the creation of csgA knockout mutants in two isolates of E. coli O157:H7. Attachment assays using epifluorescence microscopy and measurements of the force of adhesion of bacterial cells to the substrates using atomic(More)
The surface appendages and extracellular polymeric substances of cells play an important role in the bacterial adhesion process. In this work, colloidal forces and nanomechanical properties of Acidithiobacillus ferrooxidans (A. f) interacted with silicon wafer and pyrite (FeS2) surfaces in solutions of varying salt concentrations were quantitatively(More)
Here we report on the synthesis of caesium doped graphene oxide (GO-Cs) and its application to the development of a novel NO2 gas sensor. The GO, synthesized by oxidation of graphite through chemical treatment, was doped with Cs by thermal solid-state reaction. The samples, dispersed in DI water by sonication, have been drop-casted on standard(More)
The interaction between hydrophobic surfaces in aqueous solutions is particularly important because it is encountered in many industrial processes. Even though advances in surface science have been tremendous, the nature of the hydrophobic interaction remains one of the greatest challenges to the field. In this work an atomic force microscope (AFM) was used(More)
The pH dependence of the friction between a silica particle and a silica wafer was investigated using lateral force microscopy. Measurements were done in the range of 3.6 < or = pH < or = 10.6 and the effect of high loading force was also examined. It is found that the friction is independent of the pH of solutions and increases linearly with the applied(More)
Molecular-scale characteristics of friction forces between silica particles and silica wafers in aqueous solutions of the normal (pH 5.6) and high pH (pH 10.6) are investigated, using the lateral force measuring procedure of the atomic force microscope (AFM). Various significant differences of friction characteristics between solutions of normal and high(More)
Determining the influence of surface roughness on Escherichia coli O157 attachment to and detachment from stainless steel (SS) is important for controlling this foodborne pathogen. The aim of this study was to evaluate the interactions of six E. coli strains (four O157:H7, one O157:H12, and one O1:H7) with SS type 304 finishes of various surface roughness:(More)