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PI(4,5)P2-Dependent and Ca2+-Regulated ER-PM Interactions Mediated by the Extended Synaptotagmins
TLDR
It is shown that the three extended synaptotagmins (E-Syts) are ER proteins that participate in such tethering function via C2 domain-dependent interactions with the PM that require PI(4,5)P2 and E-Syt3 and also elevation of cytosolic Ca(2+) in the case of E- Syt1. Expand
Molecular Basis of Infrared Detection by Snakes
TLDR
TRPA1 orthologues from pit-bearing snakes are the most heat-sensitive vertebrate ion channels thus far identified, consistent with their role as primary transducers of infrared stimuli, and illustrate the broad evolutionary tuning of transient receptor potential (TRP) channels as thermosensors in the vertebrate nervous system. Expand
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
TLDR
By comparing human and rattlesnake TRPA1 channels, this work identifies two portable heat-sensitive modules within the ankyrin repeat-rich aminoterminal cytoplasmic domain of the snake ortholog, providing a framework for understanding how restricted changes in TRPA2 sequence account for evolution of physiologically diverse channels. Expand
UNC-13 and UNC-10/Rim Localize Synaptic Vesicles to Specific Membrane Domains
TLDR
To morphologically define the site of vesicle priming and identify fusion-competent synaptic vesicles, a rapid physical-fixation technique with immunogold staining and high-resolution morphometric analysis at Caenorhabditis elegans neuromuscular junctions is combined. Expand
Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone
TLDR
This study reveals that progesterone-activated endocannabinoid depletion by ABHD2 is a general mechanism by which progestersone exerts its genome-independent action and primes sperm for fertilization. Expand
Tomosyn Inhibits Synaptic Vesicle Priming in Caenorhabditis elegans
TLDR
Electrophysiological and ultrastructural data indicate that in the intact nervous system, TOM-1 negatively regulates synaptic vesicle priming, and hyperosmotic responses in tom-1 mutants are enhanced, indicating the primed vesicles pool is enhanced. Expand
Variant-specific [PSI+] infection is transmitted by Sup35 polymers within [PSI+] aggregates with heterogeneous protein composition.
TLDR
It is reported that disassembly of the aggregates into individual Sup 35 polymers and non-Sup35 components increases their infectivity while retaining their variant specificity, showing that variant-specific [PSI(+)] infection can be transmitted by Sup35 polymers alone. Expand
Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density
TLDR
Results suggest that vesicles targeted to the presynaptic density by RAB-3/UNC-10 interactions are ideally positioned for efficient calcium-dependent release. Expand
Neurexin in Embryonic Drosophila Neuromuscular Junctions
TLDR
This study uses a variety of techniques, including immunohistochemistry, electron microscopy, in situ hybridization, and electrophysiology, to characterize neurexin expression and phenotypes in embryonic Drosophila neuromuscular junctions, and suggests that neurxin in embryos is present both pre and postsynaptically. Expand
Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes
TLDR
This model provides a new foundation for understanding how apoA-I structure modulates HDL function and metabolism and is proposed the first experiment-based molecular model of apolipoprotein (apo) A-I in spherical HDL particles. Expand
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