Elena Moreno-Clavijo

Publications44
h-index12
Citations397
Highly Influential Citations3
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Synthesis of novel pyrrolidine 3,4-diol derivatives as inhibitors of alpha-L-fucosidases.
The stereoselective synthesis of new 3,4-dihydroxypyrrolidine derivatives starting from D-mannose, D-ribose and L-fucose is presented. Two synthetic strategies employing organometallic addition to… Expand
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Total asymmetric synthesis of monosaccharides and analogues.
Since the discovery of the 'formose reaction' by Butlerow, total synthesis of carbohydrates has undergone rapid development. The most important methods for the asymmetric synthesis of monosaccharides… Expand
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Total Synthesis of (+)-Hyacinthacine A1, (+)-7a-epi-Hyacinthacine A1, (6R)-6-Hydroxyhyacinthacine A1 and (6S)-6-Hydroxy-7a-epi-hyacinthacine A1
The total synthesis of natural (+)-hyacinthacine A1 (6), (+)-7a-epi-hyacinthacine A1 (7) and their 6-hydroxy analogues 21 and 16 was achieved using a nitrone cycloaddition strategy with… Expand
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Polyhydroxyamino‐Piperidine‐Type Iminosugars and Pipecolic Acid Analogues from a D‐Mannose‐Derived Aldehyde
A general strategy for the synthesis of diversely substituted 3,4,5-trihydroxypiperidines (including two natural products), 5-amino-3,4-dihydroxypiperidines, 3,4,5-trihydroxypipecolic acids, and… Expand
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Rapid discovery of potent α-fucosidase inhibitors by in situ screening of a library of (pyrrolidin-2-yl)triazoles.
The synthesis of a small library of (pyrrolidin-2-yl)triazoles via copper catalysed cycloaddition of an alkynyl iminocyclopentitol and a set of commercial and synthetic azides has been achieved. The… Expand
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Synthesis of a Series of Enantiopure Polyhydroxylated Bicyclic N‐Heterocycles from an L‐Erythrose‐Derived Nitrone and Alkoxyallenes
Two different lithiated alkoxyallenes and the enantiopure L-erythrose-derived cyclic nitrone (+)-3 were used as precursors for the preparation of novel bicyclic 2H-1,2-oxazine derivatives, which were… Expand
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6-Azido hyacinthacine A2 gives a straightforward access to the first multivalent pyrrolizidine architectures.
The synthesis of the first multivalent pyrrolizidine iminosugars is reported. The key azido intermediates 4 and 31 were prepared after suitable synthetic elaboration of the cycloadduct obtained from… Expand
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Synthesis and Glycosidase Inhibition Studies of 5-Methyl-Substituted Tetrahydroxyindolizidines and -pyrrolizidines Related to Natural Hyacinthacines B†
The synthesis of three tetrahydroxyindolizidines and one tetrahydroxypyrrolizidine related to natural hyacinthacines B and their biological evaluation as glycosidase inhibitors is reported. The… Expand
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Exploring a Multivalent Approach to α‐L‐Fucosidase Inhibition
To probe the utility of a multivalent approach for fucosidase inhibition, a series of di- and tri-valent imino sugars based on L-fuco-configured 1,4-imino- and 1,4-bis(imino)-cyclitol epitopes has… Expand
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Stereoselective synthesis of novel five-membered homoazasugars. A convenient route to all-cis tetrasubstituted pyrrolidines
Abstract We present a highly stereoselective procedure for the preparation of (2 S and 2 R ,3 S ,4 R ,5 S )-5-methyl-3,4-dihydroxy-2- ethoxycarbonylmethylpyrrolidines based on conjugate addition of… Expand
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