Elena G. Sokolova

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ATR is an essential kinase activated in response to DNA-replication stress, with a known target being the RPA2 subunit of human replication protein A (RPA). We find that S33-RPA2 phosphorylation by ATR occurs primarily in the late-S and G2 phases, probably at sites of residual stalled DNA-replication forks, with S33-P-RPA2 contained within nuclear repair(More)
Human replication protein A (RPA) becomes phosphorylated on the RPA2 subunit by cyclin B-Cdc2 during mitosis, although the functional role of this modification is unclear. We find that this modification stimulates RPA2 to become hyperphosphorylated in response to mitotic DNA damage caused by bleomycin treatment. Cells in which endogenous RPA2 was replaced(More)
This paper describes a multilingual text generation system in the domain of CAD/CAM software instructions for Bulgarian, Czech and Russian. Starting from a language-independent semantic representation , the system drafts natural, continuous text as typically found in software manuals. The core modules for strategic and tactical generation are implemented(More)
Despite major advances in the treatment of metastatic melanoma, treatment failure is still inevitable in most cases. Manipulation of key epigenetic regulators, including inhibition of Bromodomain and extra-terminal domain (BET) family members impairs cell proliferation in vitro and tumor growth in vivo in different cancers, including melanoma. Here, we(More)
The paper reports on the recent forum RU-EVAL ‒ a new initiative for evaluation of Russian NLP resources, methods and toolkits. It started in 2010 with evaluation of morphological parsers, and the second event RU-EVAL 2012 (2011-2012) focused on syntactic parsing. Eight participating IT companies and academic institutions submitted their results for corpus(More)
Melanoma patients with BRAFV600E -mutant tumors display striking responses to BRAF inhibitors (BRAFi); however, almost all invariably relapse with drug-resistant disease. Here, we report that microRNA-125a (miR-125a) expression is upregulated in human melanoma cells and patient tissues upon acquisition of BRAFi resistance. We show that miR-125a induction(More)