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- Elena Ezhkova, Hilda Amalia Pasolli, +5 authors Elaine Fuchs
- Cell
- 2009
Although in vitro studies of embryonic stem cells have identified polycomb repressor complexes (PRCs) as key regulators of differentiation, it remains unclear as to how PRC-mediated mechanisms… (More)
- Elena Ezhkova, W. A. Lien, N. Stokes, Hilda Amalia Pasolli, José M.P. Silva, Elaine Fuchs
- Genes & development
- 2011
Polycomb protein group (PcG)-dependent trimethylation on H3K27 (H3K27me3) regulates identity of embryonic stem cells (ESCs). How H3K27me3 governs adult SCs and tissue development is unclear. Here, we… (More)
Promoter recruitment of the Saccharomyces cerevisiae SAGA histone acetyltransferase complex is required for RNA polymerase II-dependent transcription of several genes. SAGA is targeted to promoters… (More)
Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells.
- Evan S Bardot, Victor Julián Valdes, +5 authors Elena Ezhkova
- The EMBO journal
- 2013
While the Polycomb complex is known to regulate cell identity in ES cells, its role in controlling tissue-specific stem cells is not well understood. Here we show that removal of Ezh1 and Ezh2, key… (More)
Merkel cell-neurite complexes are located in touch-sensitive areas of the mammalian skin and are involved in recognition of the texture and shape of objects. Merkel cells are essential for these… (More)
- David Llobet-Navas, Ruth RodrÃguez-Barrueco, +18 authors José M.P. Silva
- Genes & development
- 2014
The mammary gland is a very dynamic organ that undergoes continuous remodeling. The critical regulators of this process are not fully understood. Here we identify the microRNA cluster… (More)
- José M.P. Silva, Elena Ezhkova, +10 authors Gregory J Hannon
- Cell
- 2009
Identification of bona fide tumor suppressors is often challenging because of the large number of genetic alterations present in most human cancers. To evaluate candidate genes present within… (More)
miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy.
- Ruth RodrÃguez-Barrueco, Erin A. Nekritz, +10 authors José M.P. Silva
- Genes & development
- 2017
The female mammary gland is a very dynamic organ that undergoes continuous tissue remodeling during adulthood. Although it is well established that the number of menstrual cycles and pregnancy (in… (More)
- Carolina N. L. R. Perdigoto, Victor Julián Valdes, Evan S Bardot, Elena Ezhkova
- Cold Spring Harbor perspectives in medicine
- 2014
In a cell, the chromatin state is controlled by the highly regulated interplay of epigenetic mechanisms ranging from DNA methylation and incorporation of different histone variants to… (More)
- Katherine L Dauber, Carolina N. L. R. Perdigoto, Victor Julián Valdes, Francis J. Santoriello, Idan Cohen, Elena Ezhkova
- The Journal of investigative dermatology
- 2016
Polycomb repressive complex 2 (PRC2) is an essential regulator of cell physiology. Although there have been numerous studies on PRC2 function in somatic tissue development and stem cell control,… (More)