Elena Dellambra

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Graziella Pellegrini, Elena Dellambra, +6 authors Michele De Luca
Proceedings of the National Academy of Sciences…
2001

The proliferative compartment of stratified squamous epithelia consists of stem and transient amplifying (TA) keratinocytes. Some polypeptides are more abundant in putative epidermal stem cells than… (More)

R-spondin1 is essential in sex determination, skin differentiation and malignancy

Pietro Parma, Orietta Radi, +6 authors Giovanna Camerino
Nature Genetics
2006

R-spondins are a recently characterized small family of growth factors. Here we show that human R-spondin1 (RSPO1) is the gene disrupted in a recessive syndrome characterized by XX sex reversal,… (More)

Clonal analysis of stably transduced human epidermal stem cells in culture.

Monica B. Mathor, Giuliana Ferrari, +4 authors Michele De Luca
Proceedings of the National Academy of Sciences…
1996

We have transduced normal human keratinocytes with retroviral constructs expressing a bacterial beta-galactosidase (beta-gal) gene or a human interleukin-6 (hIL-6) cDNA under control of a long… (More)

Downregulation of 14-3-3σ Prevents Clonal Evolution and Leads to Immortalization of Primary Human Keratinocytes

Elena Dellambra, Osvaldo Golisano, +5 authors Michele De Luca
The Journal of cell biology
2000

In human epidermal keratinocytes, replicative senescence, is determined by a progressive decline of clonogenic and dividing cells. Its timing is controlled by clonal evolution, that is, by the… (More)

p63-microRNA feedback in keratinocyte senescence.

Pia Rivetti di Val Cervo, Anna Maria Lena, +10 authors Gerry Melino
Proceedings of the National Academy of Sciences…
2012

We investigated the expression of microRNAs (miRNAs) associated with replicative senescence in human primary keratinocytes. A cohort of miRNAs up-regulated in senescence was identified by genome-wide… (More)

Corrective transduction of human epidermal stem cells in laminin-5-dependent junctional epidermolysis bullosa.

Elena Dellambra, Joëlle Vailly, +6 authors Michele De Luca
Human gene therapy
1998

Laminin-5 is composed of three distinct polypeptides, alpha3, beta3, and gamma2, which are encoded by three different genes, LAMA3, LAMB3, and LAMC2, respectively. We have isolated epidermal… (More)

Bmi-1 reduction plays a key role in physiological and premature aging of primary human keratinocytes.

Sonia Cordisco, Riccardo Maurelli, +4 authors Elena Dellambra
The Journal of investigative dermatology
2010

Accumulation of senescent cells contributes to the reduced regenerative capacity in aged tissues. By evaluating the molecular pathways of senescence in relation to proliferative potential of primary… (More)

Inactivation of p16INK4a (inhibitor of cyclin-dependent kinase 4A) immortalizes primary human keratinocytes by maintaining cells in the stem cell compartment.

Riccardo Maurelli, Giovanna Zambruno, +5 authors Elena Dellambra
FASEB journal : official publication of the…
2006

Replicative senescence of human keratinocytes is determined by a progressive decline of clonogenic and dividing cells, and its timing is controlled by clonal evolution (i.e., the transition from stem… (More)

Oxidative Stress-Induced miR-200c Disrupts the Regulatory Loop Among SIRT1, FOXO1, and eNOS.

Fabrizio Carlomosti, Marco D'Agostino, +14 authors Alessandra Magenta
Antioxidants & redox signaling
2017

AIMS Reactive oxygen species (ROS) play a pivotal role in different pathologic conditions, including ischemia, diabetes, and aging. We previously showed that ROS enhance miR-200c expression, causing… (More)

Vitiligo: pathogenetic hypotheses and targets for current therapies.

Liliana Guerra, Elena Dellambra, Serena Brescia, Desanka Raskovic
Current drug metabolism
2010

Vitiligo is a multifactorial disorder characterized by the appearance of white maculae that may spread over the entire body skin. Depigmentation arises from the loss of functioning melanocytes. Non… (More)

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