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The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating beta 2 integrin affinity and valency in neutrophils, but are required for beta 2…

• Cinzia Giagulli, Linda Ottoboni, +5 authors Giorgio Berton
• Journal of immunology
• 2006

Neutrophil beta(2) integrins are activated by inside-out signaling regulating integrin affinity and valency; following ligand binding, beta(2) integrins trigger outside-in signals regulating cell… (More)

Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages.

• Patrick W. Suen, Dusko Ilic, Elena Caveggion, Giorgio Berton, Caroline H. Damsky, Clifford A Lowell
• Journal of cell science
• 1999

Integrin-mediated adhesion of monocytes and macrophages initiates a signal transduction pathway that leads to actin cytoskeletal reorganization, cell migration and immunologic activation. This… (More)

Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion.

• Meytham Majeed, Elena Caveggion, Clifford A Lowell, Giorgio Berton
• Journal of leukocyte biology
• 2001

Phagocytosis is increased by Fcgamma receptors (FcgammaRs), and studies with syk(-/-) macrophages demonstrated that Syk kinase is required for FcgammaR phagocytosis. Similar studies with macrophages… (More)

Regulation of phagocyte migration and recruitment by Src-family kinases

• Anna Baruzzi, Elena Caveggion, Giorgio Berton
• Cellular and Molecular Life Sciences
• 2008

Src-family kinases (SFKs) regulate different granulocyte and monocyte/macrophage responses. Accumulating evidence suggests that members of this family are implicated in signal transduction pathways… (More)

Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation.

• Lucia Vicentini, Paola Mazzi, +5 authors Giorgio Berton
• Journal of immunology
• 2002

Using a mouse model of allergic lung inflammation, we found that mice deficient of Fgr, a Src family tyrosine kinase highly expressed in myelomonocytic cells, fail to develop lung eosinophilia in… (More)

The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.

• Silvia Continolo, Anna Baruzzi, +4 authors Giorgio Berton
• Experimental cell research
• 2005

Fgr participates in integrin signaling in myeloid leukocytes. To examine the role of its specific domains in regulating cell migration, we expressed various Fgr molecules in COS-7 cells. Full-length,… (More)

Glucose kinetics in interstitial fluid can be predicted by compartmental modeling.

• Amalia Gastaldelli, Jorg M. Schwarz, +6 authors Robert R. Wolfe
• The American journal of physiology
• 1997

The purposes of this study were to define in sheep a compartmental model for glucose kinetics in the basal condition and to test the hypothesis that interstitial fluid obtained by sampling thoracic… (More)

The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines.

• Paola Mazzi, Elena Caveggion, Josè A Lapinet-Vera, Clifford A Lowell, Giorgio Berton
• Journal of immunology
• 2015

Myeloid leukocyte recruitment into the lung in response to environmental cues represents a key factor for the induction of lung damage. We report that Hck- and Fgr-deficient mice show a profound… (More)

Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement.

• Elena Caveggion, Silvia Continolo, +4 authors Giorgio Berton
• Journal of cellular physiology
• 2003

Primary macrophages isolated from hck(-/-)fgr(-/-) mice display altered morphology and F-actin cytoskeletal structures and reduced migration. The ability of phorbol myristyl acetate (PMA), a protein… (More)

Bicarbonate kinetics in humans: identification and validation of a three-compartment model.

• Maria Pia Saccomani, Riccardo C Bonadonna, Elena Caveggion, Ralph A DeFronzo, Claudio Cobelli
• The American journal of physiology
• 1995

A model of bicarbonate kinetics is crucial to a correct interpretation of experiments for measuring oxidation in vivo of carbon-labeled compounds. The aim of this study is to develop a compartmental… (More)

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