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We reconsider the issue of large-volume compactifications of the heterotic string in light of the recent discoveries about strongly-coupled string theories. Our conclusion remains firmly negative with respect to classical compactifica-tions of the ten-dimensional field theory, albeit for a new reason: When the internal sixfold becomes large in heterotic(More)
Ubiquitin is essential for eukaryotic life and varies in only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies indicate that ubiquitin is highly tolerant to single mutations. We hypothesized that this tolerance would be reduced by chemically induced physiologic perturbations. To test this hypothesis, a class of first(More)
28 29 Ubiquitination is an essential post-translational regulatory process that can control protein stability, 30 localization, and activity. Ubiquitin is essential for eukaryotic life and is highly conserved, varying in 31 only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies 32 in S. cerevisiae indicate that(More)
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