Elena B. Dzambazova

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Involvement of endogenous nitric oxide in the effects of kyotorphin and its synthetic analogue on immobilization and cold stress-induced analgesia E. B. Dzambazova*, A. I. Bocheva, V. P. Nikolova 1 Department of Pathophysiology, Faculty of Medicine, Medical University, 2 Zdrave Str., 1431 Sofia, Bulgaria 2 Department of Biology, Faculty of Medicine, Medical(More)
Endogenous opioid peptides take part in various functions as hormones or neuromodulators. In 1979, Takagi and his co-workers identified a new morphine-like substance “kyotorphin” (Kyo) a dipeptide synthesized in specific brain regions. The highest levels were found in the lower brain stem and dorsal spinal cord areas closely associated with the pain(More)
The Tyr-MIF-1 family of neuropeptides (Tyr-MIF-1’s) includes MIF-1, Tyr-MIF-1, Tyr-W-MIF-1 and Tyr-K-MIF-1. Nowadays it is certain that they can modulate pain and some forms of stress-induced analgesia (SIA) by antiopiate and μ-specific processes. The objectives of the present study were twofold: 1) to determine the involvement of opioid system in analgesia(More)
1. Studies, using a wide variety of stressors, have clearly indicated that the pattern of neuroendocrine response is dependent upon the stress stimulus applied. 2. The Tyr-MIF-1 family of peptides (Tyr-MIF-1s) includes MIF-1, Tyr-MIF-1, Tyr-W-MIF-1 and Tyr-K-MIF-1. These neuropeptides, neuromodulators are able to inhibit the expression of some forms of(More)
d-kyotorphin (d-Kyo) is a synthetic analogue of the neuropeptide kyotorphin and produces naloxone reversible analgesia. Stress-induced analgesia (SIA) is an in-built mammalian pain-suppression response that occurs during or following exposure to a stressful stimulus. The periaqueductal gray (PAG) is implicated as a critical site for processing strategies(More)
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