Elena A. Uvarova

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76 The advantages of plants as alternative systems for expression of heterologous proteins are illustrated by numerous examples of accumulation in plant tissues of complex functionally active immunoglobulins, secretory granules, collagen, hemoglobin, and cytokines [1]. Transgenic plants accumulating antigens against various pathogens can be used as edible(More)
The elimination of variola, an extremely dangerous human epidemic disease, was the first and still remains the only example of a successful fight of the international community against an infectious disease under the aegis of World Health Organization [1]. The success of this campaign was to a large extent due to the fact that variola virus, which belongs(More)
The human complement system consists of more than twenty serum proteins and at least ten membraneassociated proteins. The mechanism of antiviral action of the complement system involves virus neutralization and opsonization, lysis of infected cells, and enhancement of nonspecific inflammatory and specific immune response [1]. The vaccinia virus protein(More)
Two lines of transgenic carrot plants producing Mycobacterium tuberculosis proteins (ESAT6 and CFP10) have been constructed. The target proteins are present in carrot storage roots at a level not less than 0.056% of the total storage protein (TSP) for ESAT6 and 0.002% of TSP for CFP10. As has been shown, oral immunization of mice induces both the(More)
Tuberculosis remains one of the major infectious diseases, which continues to pose a major global health problem. Transgenic plants may serve as bioreactors to produce heterologous proteins including antibodies, antigens, and hormones. In the present study, a genetic construct has been designed that comprises the Mycobacterium tuberculosis genes cfp10,(More)
Transgenic plants as an alternative of costly systems of recombinant immunogenic protein expression are the source for the production of cheap and highly efficient biotherapeuticals of new generation, including plant vaccines. In the present review, possibilities of plant system application for the production of recombinant proteins for veterinary use are(More)
In humans, monkey pox clinical signs are similar to those of smallpox. The main distinction between these infections is lymphadenopathy—a pronounced inflammatory reaction, which is characteristic of the patients with monkeypox but absent in the patients with smallpox. Complement activation is one of the major mechanisms of inflammation. The smallpox virus(More)
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