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- Timothy M. Frayling, Nicholas J. Timpson, +38 authors Mark I. McCarthy
- Science
- 2007
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type… (More)
- Josée Dupuis, Claudia Langenberg, +300 authors Inês Barroso
- Nature Genetics
- 2010
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting… (More)
- Cristen J. Willer, Elizabeth K. Speliotes, +142 authors Joel Hirschhorn
- Nature Genetics
- 2009
Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide… (More)
- Eleftheria Zeggini, Laura J. Scott, +95 authors David Altshuler
- Nature Genetics
- 2008
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Established associations to common and… (More)
- Eleftheria Zeggini, M. N. Weedon, +23 authors Andrew T Hattersley
- Science
- 2007
The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 population controls generated… (More)
- Benjamin F. Voight, Laura J. Scott, +155 authors Mark I. McCarthy
- Nature Genetics
- 2010
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a… (More)
- Andrew P. Morris, Benjamin F. Voight, +201 authors Mark I. McCarthy
- Nature Genetics
- 2012
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and… (More)
- Ruth J. F. Loos, Cecilia M. Lindgren, +98 authors Inês Barroso
- Nature Genetics
- 2008
To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the… (More)
- Andrew P. Morris, Eleftheria Zeggini
- Genetic epidemiology
- 2010
Genome-wide association (GWA) studies have proved to be extremely successful in identifying novel common polymorphisms contributing effects to the genetic component underlying complex traits.… (More)
- Paul R. Burton, David G. Clayton, +209 authors Mathew Brown
- Nature Genetics
- 2007
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease… (More)