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MEK1 activation by PAK: a novel mechanism.
Extracellular signal-Regulated Kinase (ERK) controls a variety of cellular processes, including cell proliferation and cell motility. While oncogenic mutations in Ras and B-Raf result in deregulatedExpand
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Homozygous loss of mouse tetraspanin CD82 enhances integrin αIIbβ3 expression and clot retraction in platelets.
Integrin αIIbβ3 is critical for platelet-mediated blood clotting. Tetraspanins are well-established regulators of integrins and genetic loss of tetraspanin CD151 or TSSC6 in mice leads to increasedExpand
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Differential requirement for MEK Partner 1 in DU145 prostate cancer cell migration
ERK signaling regulates focal adhesion disassembly during cell movement, and increased ERK signaling frequently contributes to enhanced motility of human tumor cells. We previously found that the ERKExpand
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CD82 and Cell-Cell Adhesion in Metastatic Prostate Cancer
Abstract : CD82 is a non enzymatic transmembrane molecular scaffold that was initially identified as a metastasis suppressor in the rat AT6.1 prostate tumor model (1). CD82 has been shown to regulateExpand