Eleanor E. Deschner

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Dietary quercetin (QU) and rutin (RU), phenolic flavonoids commonly found in many fruits and vegetables, were provided to CF1 female mice for 50 weeks to assess the ability of these compounds to inhibit azoxymethanol (AOM)-induced colonic neoplasia. In addition to a control group fed an AIN 76A diet, five other groups received that diet to which was added(More)
The suitability of carcinogen-induced colon tumors in mice for chemotherapy investigations and the potential antitumoral activity of a new anthracycline, 4'-deoxydoxorubicin (4' deoDX ) were evaluated. The latter was compared with 5-fluorouracil (5-FU) and doxorubicin (DX) either alone or in combination. CF1 mice were given 10 weekly subcutaneous injections(More)
In vivo measurements of the proliferation kinetics of epithelial cells in human adenomas were made following i.v. pulse injec tion of tritiated thymidine ([3H]dThd), in a patient with familial polyposis and Gardner syndrome. In the adenomas and in adjacent flat mucosa, biopsies were taken and microautoradiographs were prepared at intervals after injection.(More)
Curcumin, a major yellow pigment of turmeric obtained from powdered rhizomes of the plant Curcuma longa Linn., is commonly used as a coloring agent in foods, drugs and cosmetics. Ascorbyl palmitate is a lipid soluble derivative of ascorbic acid. Both curcumin and ascorbyl palmitate have antioxidant activity and are potent inhibitors of(More)
Early lesions in the colonic mucosa of humans and rodents are characterized by similar proliferative changes within their epithelial cell population. Progressive phases of abnormal cell development appear during the evolution of neoplastic transformation in colonic cells of rodents exposed to chemical carcinogens and in humans highly susceptible to(More)
Colorectal tumor yield and volume data were obtained using 355 CF1 mice serially sacrificed up to 84 weeks following various dose levels of the carcinogen 1,2-dimethylhydrazine dichloride (DMH). Several conclusions were reached: (a) With increasing doses of DMH, there was an increased tumor yield and decreased latency period. (b) With repeated doses, there(More)
Adenoma formation in the colon has been shown to be initiated by an alteration in the genetic make-up which controls the repopulation of the mucosa. This defect is recognized primarily by an upward displacement of the major zone of DNA synthesis within one or a few crypts. Progression to a microadenoma involves an elevation of cell proliferation within(More)