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bHLH-PAS proteins represent a class of transcription factors involved in diverse biological activities. Previous experiments demonstrated that the PAS domain confers target specificity (Zelzer et al., 1997. Genes Dev. 11, 2079-2089). This suggested an association between the PAS domain and additional DNA-binding proteins, which is essential for the(More)
Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis during development, but little is known about the factors that control its expression. We provide the first example of tissue specific loss of VEGF expression as a result of targeting a single gene, Cbfa1/Runx2. During endochondral bone formation, invasion of blood vessels(More)
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