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Inner-ear hair cell differentiation requires Atoh1 function, while Eya1, Six1, and Sox2 are coexpressed in sensory progenitors and mutations in these genes cause sensorineural hearing loss. However, how these genes are linked functionally and the transcriptional networks controlling hair cell induction remain unclear. Here, we show (1) that Eya1/Six1 are(More)
A striking feature of vestibular hair cells is the polarized arrangement of their stereocilia as the basis for their directional sensitivity. In mammals, each of the vestibular end organs is characterized by a distinct distribution of these polarized cells. We utilized the technique of post-fixation transganglionic neuronal tracing with fluorescent lipid(More)
The facial width-to-height ratio (fWHR) has been identified as a reliable predictor of men's behavior, with researchers focusing on evolutionary selection pressures as the underlying mechanism explaining these relationships. In this paper, we complement this approach and examine the extent to which social processes also determine the extent to which men's(More)
The phosphatase-transactivator EYA1 interacts with the homeodomain protein SIX1 to form transcriptional activation complexes, which play essential roles in regulating cell proliferation, survival and induction of sensory and neuronal differentiation programs during inner ear development. Mutations of the Eya1 and Six1 genes cause profound developmental(More)
The spatial regulation of combinatorial expression of Hox genes is critical for determining hindbrain rhombomere (r) identities. To address the cross-regulatory relationship between Hox genes in hindbrain neuronal specification, we have generated a gain-of-function transgenic mouse mutant Hoxb3(Tg) using the Hoxb2 r4-specific enhancer element.(More)
Recent research has identified men's facial width-to-height ratio (fWHR) as a reliable predictor of aggressive tendencies and behavior. Other research, however, has failed to replicate the fWHR-aggression relationship and has questioned whether previous findings are robust. In the current paper, we synthesize existing work by conducting a meta-analysis to(More)
In this paper, we evaluate the ability of four able-bodied participants to discriminate the articulation location for spoken consonants, using tactile cues presented on the dorsal side of their forearm. Additionally, we determine the processing capability of the dorsal forearm's skin with a tactile sleeve worn by ten participants using two psychophysical(More)
Mouse N-ethyl-N-nitrosourea (ENU) mutagenesis has generated many useful animal models for human diseases. Here we describe the identification of a novel ENU-induced mouse mutant strain Turner (Tur) that displays circling and headtossing behavior and progressive hearing loss. Tur/Tur homozygous animals lack Preyer and righting reflexes and display severe(More)
The spatial regulation of combinatorial expression of Hox genes is critical for determining hindbrain rhombomere (r) identities. To address the cross-regulatory relationship between Hox genes in hindbrain neuronal specification, we have generated a gain-of-function transgenic mouse mutant Hoxb3 Tg using the Hoxb2 r4-specific enhancer element. Interestingly,(More)
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