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BACKGROUND The aim of this study was to evaluate the diagnostic accuracy of bronchodilator responsiveness for asthma in 5-10 year old children. METHODS Spirometric measurements were made in 142 children (58 wheezers) before and after 400 mug inhaled salbutamol. RESULTS On a receiver operating characteristic curve, a 9% increase in predicted forced(More)
BACKGROUND To be able to interpret any measurement, its repeatability should be known. This study reports the repeatability of airway resistance measurements using the interrupter technique (Rint) in children with and without respiratory symptoms. METHODS Children aged 2-10 years who were healthy, had persistent isolated cough, or who had previous wheeze(More)
Despite heterologous expression of epitope-tagged GPCR is widely adopted for functional characterization, there is lacking of systematic analysis of the impact of expression host and epitope tag on GPCR expression. Angiotensin type II (AT2) receptor displays agonist-dependent and -independent activities, coupling to a spectrum of signaling molecules.(More)
Antibody repertoires for library construction are conventionally harvested from mRNAs of immune cells. To examine whether germline rearranged immunoglobulin (Ig) variable region genes could be used as source of antibody repertoire, an immunized phage-displayed scFv library was prepared using splenocytic genomic DNA as template. In addition, a novel(More)
In this paper, we develop a semi-supervised regression algorithm to analyze data sets which contain both categorical and numerical attributes. This algorithm partitions the data sets into several clusters and at the same time fits a multivariate regression model to each cluster. This framework allows one to incorporate both multivariate regression models(More)
Long-term non-invasive ventilation (NIV) is a common modality of breathing support used for a range of sleep and respiratory disorders. The aim of this scoping review was to provide a summary of the literature relevant to long-term NIV use in children. We used systematic methodology to identify 11,581 studies with final inclusion of 289. We identified 76(More)
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