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- Cristen J. Willer, Elizabeth K. Speliotes, +142 authors Joel Hirschhorn
- Nature Genetics
- 2009
Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide… (More)
- Karol Estrada, Unnur Styrkarsdottir, +178 authors Fernando Rivadeneira
- Skeletal Radiology
- 2012
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide… (More)
- Holly Emma Syddall, Avan Aihie Sayer, Elaine M. Dennison, Helen J Martin, David J. P. Barker, Cyrus Cooper
- International journal of epidemiology
- 2005
1234 be related to low birth weight in these men and women, and to low weight at 1 year among the men.3 This was the first study based on individual (rather than ecological) level data to demonstrate… (More)
Records from the General Practice Research Database were used to derive age- and gender-specific fracture incidence rates for England and Wales during the period 1988-1998. In total, 103,052 men and… (More)
- Cyrus Cooper, Zoe A. Cole, +6 authors J. A. Kanis
- Osteoporosis International
- 2011
Osteoporosis constitutes a major public health problem through its association with age-related fractures, most notably those of the proximal femur. Substantial geographic variation has been noted in… (More)
- Cyrus Cooper, Elaine M. Dennison, Herbert G M Leufkens, Nicholas S. Bishop, Tjeerd P van Staa
- Journal of bone and mineral research : the…
- 2004
UNLABELLED
A population-based British cohort study, including approximately 6% of the population, was used to derive age- and sex-specific incidence rates of fractures during childhood. Fractures… (More)
- Rona J. Strawbridge, Josée Dupuis, +100 authors Jose C Florez
- Diabetes
- 2011
OBJECTIVE
Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and… (More)
- Richard Matthew Dodds, Holly Emma Syddall, +16 authors Avan Aihie Sayer
- PloS one
- 2014
INTRODUCTION
Epidemiological studies have shown that weaker grip strength in later life is associated with disability, morbidity, and mortality. Grip strength is a key component of the sarcopenia and… (More)
- Emma L. Duncan, Patrick Danoy, +44 authors Matthew A Brown
- PLoS genetics
- 2011
Osteoporotic fracture is a major cause of morbidity and mortality worldwide. Low bone mineral density (BMD) is a major predisposing factor to fracture and is known to be highly heritable. Site-,… (More)
- Dinesh Kumar Dhanwal, Elaine M. Dennison, N. C. W. Harvey, Cyrus Cooper
- Indian journal of orthopaedics
- 2011
Osteoporosis is a major health problem, especially in elderly populations, and is associated with fragility fractures at the hip, spine, and wrist. Hip fracture contributes to both morbidity and… (More)