Elaine Chinyere Azinge

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Liver fibrosis and cirrhosis are common sequelae to diverse liver injuries in the tropics or Nigeria. The development of hepatic fibrosis or cirrhosis is due to increased synthesis, deposition, and possibly reduced degradation of hepatic extracellular matrix components, especially collagens, such as interstitial type I and III, basement membrane type IV,(More)
Prediction equations of body composition based on measurements of whole-body bioelectrical impedance analysis (BIA) have been found to be population-specific. It was hypothesised that this may be, in part, due to differences in proportional limb lengths between ethnic or racial groups. As a preliminary to a survey of body composition in urban Nigerians(More)
BACKGROUND Many studies have found an association between sodium intake and blood pressure. Salt taste threshold is thought to be another marker of sodium intake. OBJECTIVE This study sought to assess two markers of sodium intake, 24-hour-urinary sodium and salt-taste threshold. We also determined the relationship between these two markers and blood(More)
BACKGROUND Salt-sensitivity increases the risk for the development of high blood pressure in susceptible persons and also increases the risk for cardiovascular events and mortality. OBJECTIVE The study is to determine the pattern of salt-sensitivity among normotensive and hypertensive Nigerians. METHODS Twenty-eight (28) hypertensive subjects (HT) and(More)
Osteocalcin or bone gamma-carboxyglutamic acid (gla) protein and Bone-specific alkaline phosphatase (b-AP) total protein levels were evaluated as indicators of bone turnover in twenty patients with sickle cell haemoglobinopathies and in twenty normal healthy individuals. The serum bone-specific alkaline phosphatase total protein level was measured by(More)
BACKGROUND Over the past decade, Lagos state has witnessed greater industrialization and increased economic prosperity. Lifestyle has become increasingly westernized, characterised by intake of excesscalories and physical inactivity. It is possible that these changes would lead to increases in the prevalence of metabolic syndrome and type 2 diabetes which(More)
Sickle cell disease commonly causes avascular necrosis of bone. Plain radiographs are not useful if obtained early in the disease. Radionuclide scans do not appear to increase the sensitivity of the diagnosis. Magnetic resonance imaging can detect disease but this is expensive and hard to employ on a routine or regular basis. The determination of the(More)
BACKGROUND Preeclampsia is a multisystem disorder associated with high maternal and perinatal mortality and morbidity. The cause of the disorder is largely unknown and its pathogenesis is complex and poorly understood. Calcium and magnesium are divalent ions which may have roles to play in the manifestations of the disease. An understanding of their(More)
BACKGROUND Leptin is a hormone produced directly from adipocytes and has been associated with type 2 diabetes mellitus (T2DM) which is characterized by insulin resistance (IR). Due to the increasing prevalence of obesity in sub-Saharan Africa, serum leptin can be explored as a predictive risk factor for T2DM. Therefore, the aim of this study was to(More)