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Genomes are organized into high-level three-dimensional structures, and DNA elements separated by long genomic distances can in principle interact functionally. Many transcription factors bind to regulatory DNA elements distant from gene promoters. Although distal binding sites have been shown to regulate transcription by long-range chromatin interactions(More)
Mammalian genomes are viewed as functional organizations that orchestrate spatial and temporal gene regulation. CTCF, the most characterized insulator-binding protein, has been implicated as a key genome organizer. However, little is known about CTCF-associated higher-order chromatin structures at a global scale. Here we applied chromatin interaction(More)
Genomes are organized into high-level 3-dimensional structures, and DNA elements separated by long genomic distances could functionally interact. Many transcription factors bind to regulatory DNA elements distant from gene promoters. While distal binding sites have been shown to regulate transcription by long-range chromatin interactions at a few loci,(More)
Abstract. Computer models for determining key boundaries are important tools for computer analysis of music, computational modeling of music cognition, content-based categorization and retrieval of music information and automatic generating of expressive performance. This paper proposes a Boundary Search Algorithm (BSA) for determining points of modulation(More)
This paper presents algorithms for pitch spelling using the Spiral Array model. Accurate pitch spelling, assigning contextually consistent letter names to pitch numbers (for example, MIDI), is a critical component of music transcription and analysis systems. The local context is found to be more important than the global, but a combination of both achieves(More)
In this article, we propose a solution to the problem of query by example for polyphonic music audio. We first present a generic mid-level representation for audio queries. Unlike previous efforts in the literature, the proposed representation is not dependent on the different spectral characteristics of different musical instruments and the accurate(More)