Elźbieta Kozłowska

Learn More
Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading extracellular matrix. Their role has been emphasized in tumor invasion, metastasis and tumor-induced angiogenesis. The gene encoding MMP-3 is polymorphic and an insertion (6A)/deletion (5A) polymorphism (5A/6A polymorphism) in the MMP-3 gene may have functional significance in the(More)
Apoptotic cell death plays a central role in the pathogenesis and disease progression of cancer as well as in the response to treatment. In the present work we investigated the association between the presence of apoptotic peripheral blood cells in breast and ovarian cancer progression. Apoptosis was analysed in blood cells of breast (n=82) and ovarian(More)
The development of breast cancer is associated with an accumulation of specific genetic alterations. These genetic changes affect malignant transformation of both dysregulation of cell proliferation and apoptosis. Apoptotic cell death is a frequent phenomenon in breast cancer. In present work we investigated the association between apoptosis and breast(More)
Susceptibility to colorectal cancer appears to be linked to germ-line mutations in genes causing various familial cancer syndromes. The objectives of this study were to determine microsatellite instability and the frequency of BRCA1 germ-line mutations in patients with family history of cancer. The study population consisted of 30 patients from HNPCC(More)
UNLABELLED Microsatellite instability (MSI) is due to defective DNA mismatch repair and is characteristic of HNPCC tumours. THE AIM The role of MSI in familial predisposition to colorectal cancer was investigated in this study by microsatellite analysis among familial cases. MATERIAL AND METHODS PCR-based microsatellite analysis was performed in blood(More)
In recent years several novel prognostic determinants of breast cancer have been identified, including HER-2/neu. The oncogene called HER-2/neu or c-erbB-2 located at 17q21 encodes a 185-kD transmembrane glycoprotein, p185. The HER-2/neu gene is frequently overexpressed in human breast cancers as a result of gene amplification and/or elevated transcription.(More)
  • 1