Ekaterina R Kim

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In eukaryotic cells, degradation of most intracellular proteins is realized by proteasomes. The substrates for proteolysis are selected by the fact that the gate to the proteolytic chamber of the proteasome is usually closed, and only proteins carrying a special "label" can get into it. A polyubiquitin chain plays the role of the "label": degradation(More)
The Y-box binding protein 1 (YB-1) is a DNA/RNA-binding nucleocytoplasmic shuttling protein whose regulatory effect on many DNA and RNA-dependent events is determined by its localization in the cell. We have shown previously that YB-1 is cleaved by 20S proteasome between E219 and G220, and the truncated N-terminal YB-1 fragment accumulates in the nuclei of(More)
Multifunctional protein YB-1, which takes a part in many DNA/RNA-associated events in cells (transcription, mRNA translation, splicing) is a promising prognostic and predictive marker for various human tumors. Recently it was discovered that protein YB-1 secreted by cells functions as an extracellular mitogen. These results were obtained on kidney mesangial(More)
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