Ekaterina N Proshkina

Learn More
DNA repair declines with age and correlates with longevity in many animal species. In this study, we investigated the effects of GAL4-induced overexpression of genes implicated in DNA repair on lifespan and resistance to stress factors in Drosophila melanogaster. Stress factors included hyperthermia, oxidative stress, and starvation. Overexpression was(More)
The molecular mechanisms that determine the organism's response to a variety of doses and modalities of stress factors are not well understood. We studied effects of ionizing radiation (144, 360 and 864 Gy), entomopathogenic fungus (10 and 100 CFU), starvation (16 h), and cold shock (+4, 0 and -4°C) on an organism's viability indicators (survival and(More)
The pharmacological activation of stress-defense mechanisms is one of the perspective ways to increase human lifespan. The goal of the present study was to study the effects on lifespan of Drosophila melanogaster and Caenorhabditis elegans of two carotenoids: ß-carotene and fucoxanthin, which are bioactive natural substances in human diet. In addition, the(More)
Transcriptional changes that contribute to the organism’s longevity and prevent the age-dependent decline of biological functions are not well understood. Here, we overexpressed pro-longevity gene encoding glutamate-cysteine ligase catalytic subunit (Gclc) and analyzed age-dependent changes in transcriptome that associated with the longevity, stress(More)
Drosophila is one of the most convenient model organisms in the genetics of aging and longevity. Unlike the nematodes, which allow for the detection of new pro-aging genes by knockout and RNAi-mediated knock-down, Drosophila also provides an opportunity to find new pro-longevity genes by driver-induced overexpression. Similar studies on other models are(More)
Alexey Moskalev, Vladimir Anisimov, Aleksander Aliper, Artem Artemov, Khusru Asadullah, Daniel Belsky, Ancha Baranova, Aubrey de Grey, Vishwa Deep Dixit, Edouard Debonneuil, Eugenia Dobrovolskaya, Peter Fedichev, Alexander Fedintsev, Vadim Fraifeld, Claudio Franceschi, Rosie Freer, Tamas Fülöp, Jerome Feige, David Gems, Vadim Gladyshev, Vera Gorbunova,(More)
Lifespan is a complex quantitative trait, which makes a significant contribution to Darwinian fitness. The understanding of the genetic structure of longevity is a fundamental problem of the evolution of ontogeny, evolutionary genetics, and molecular gerontology. Under optimal conditions, lifespan is determined by the aging rate. Aging is made up of(More)
The modulation of longevity genes and aging-associated signaling pathways using pharmacological agents is one of the potential ways to prolong the lifespan and increase the vitality of an organism. Phytochemicals flavonoids and non-steroidal anti-inflammatory drugs have a large potential as geroprotectors. The goal of the present study was to investigate(More)
  • 1