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BACKGROUND Clinical trial design is challenging in irritable bowel syndrome (IBS) due in part to a high placebo effect. We postulated that the mere presence of an adverse event (AE) may unmask patients in clinical trials who are assigned to the active agent, and this may lead to higher reported efficacy. METHODS We evaluated therapies receiving at least a(More)
Técnica de conteo de items bayesiana mejorada usando diferentes distribuciones a priori Abstract Item Count Technique (ICT) serves the purpose of estimating the proportion of the people with stigmatizing attributes using the indirect questioning method. An improved ICT has been recently proposed in the literature (not requiring two subsamples and hence free(More)
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