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OBJECTIVES To review the evidence from controlled clinical trials of neonates given equal daily aminoglycoside doses as extended interval dosing (dosage interval typically 24 hours in term and 36-48 hours in immature neonates) compared with traditional dosing (dosage interval typically 8-12 hours in term and 12-24 hours in immature neonates). DESIGN(More)
The stability of penicillin G during production is reviewed and compared to reports on end-product regulation of penicillin biosynthesis. From this analysis, it appears that penicillin control of its own synthesis when added exogenously at the beginning of the process has not been proven, since the apparent decrease of net accumulation can be explained by(More)
BACKGROUND Superior vena cava (SVC) flow has become a surrogate measure of systemic blood flow in neonates. OBJECTIVE The aim of this study was to establish normal SVC flow values in healthy term infants the first 3 days of life and to evaluate the feasibility and reliability of the off-line analyses. DESIGN Doppler echocardiography of SVC flow was(More)
Transthoracic echocardiography (TTE) is an important tool for diagnosis and follow-up of patients with congenital heart disease (CHD). Appropriate use of TTE can reduce the need for more invasive and complex modalities, such as cardiac catheterization and cardiac magnetic resonance imaging. New echocardiographic techniques have emerged for the assessment of(More)
BACKGROUND Sparse knowledge exists on the differences in cardiac function between term and preterm infants. This study examines the impact of heart size, gestational age and postnatal maturation on myocardial function. AIM To assess and compare serial echocardiographic indices of myocardial function in term and moderately preterm infants. METHODS(More)
BACKGROUND Very preterm newborn infants often need cardiovascular support. More knowledge about myocardial function and factors that influence the immature myocardium may be helpful for optimising cardiovascular support in these infants. OBJECTIVE Serial assessment of global myocardial function by means of colour tissue Doppler imaging (cTDI) in very and(More)
OBJECTIVES Gestational and chronological age may have an impact on myocardial function. We studied the longitudinal changes of the atrioventricular tissue Doppler velocities in premature infants through the neonatal transitional period and at expected term and explored the reproducibility of the measurements. DESIGN Prospective, observational and(More)
BACKGROUND There is a lack of standardized echocardiographic parameters to quantify ventricular function in newborn infants. Long-axis systolic ventricular shortening is a useful parameter of global ventricular function. AIMS Serial assessment of long-axis systolic atrioventricular annulus excursion in premature infants. METHODS Two-centre, prospective(More)
The function of the heart was studied in 20 asphyxiated term neonates by measuring the longitudinal peak systolic strain and peak systolic strain rate by tissue Doppler in 18 segments of the heart on days 1, 2, and 3 of life. The fractional shortening was assessed at each examination as well. Measurements were compared against measurements in 48 healthy(More)
Tissue Doppler derived longitudinal strain and strain rate were studied in 48 healthy term neonates by measuring peak systolic strain (PSS) and peak systolic strain rate (PSSR) in 18 heart segments on day 1-3 of life. The mean PSS for each examination was -21.8% (-22.1, -21.4) [mean (95%CI)], and the mean PSSR was -1.78/s (-1.81, -1.74). Age (d), fetal(More)