Eiram Elahi

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Whereas the human linkage map appears on limited evidence to be constant over populations, maps of linkage disequilibrium (LD) vary among populations that differ in gene history. The greatest difference is between populations of sub-Saharan origin and populations remotely derived from Africa after a major bottleneck that reduced their heterozygosity and(More)
Ionising radiation is a carcinogen capable of inducing tumours, including colorectal cancer, in both humans and animals. By backcrossing a recombinant line of Apc(Min/+) mice to the inbred BALB/c mouse strain, which is unusually sensitive to radiation-induced tumour development, we obtained panels of 2Gy-irradiated and sham-irradiated N2 Apc(Min/+) mice for(More)
BACKGROUND Methylation-induced silencing of promoter CpG islands in tumor suppressor genes plays an important role in human carcinogenesis. In colorectal cancer, the CpG island methylator phenotype (CIMP) is defined as widespread and elevated levels of DNA methylation and CIMP+ tumors have distinctive clinicopathological and molecular features. In contrast,(More)
BACKGROUND Next generation sequencing (NGS) promises many benefits for clinical diagnostics. However, current barriers to its adoption include suboptimal amenability for low clinical throughputs and uncertainty over data accuracy and analytical procedures. We assessed the feasibility and performance of low-throughput NGS for detecting germline mutations for(More)
MEDICAL SCIENCES. For the article ‘‘Linkage disequilibrium in human populations,’’ by Christine Lonjou, Weihua Zhang, Andrew Collins, William J. Tapper, Eiram Elahi, Nikolas Maniatis, and Newton E. Morton, which appeared in issue 10, May 13, 2003, of Proc. Natl. Acad. Sci. USA (100, 6069–6074; First Published April 29, 2003; 10.1073 pnas.1031521100), due to(More)
MEDICAL SCIENCES. For the article ‘‘Linkage disequilibrium in human populations,’’ by Christine Lonjou, Weihua Zhang, Andrew Collins, William J. Tapper, Eiram Elahi, Nikolas Maniatis, and Newton E. Morton, which appeared in issue 10, May 13, 2003, of Proc. Natl. Acad. Sci. USA (100, 6069–6074; First Published April 29, 2003; 10.1073 pnas.1031521100), due to(More)
MEDICAL SCIENCES. For the article ‘‘Linkage disequilibrium in human populations,’’ by Christine Lonjou, Weihua Zhang, Andrew Collins, William J. Tapper, Eiram Elahi, Nikolas Maniatis, and Newton E. Morton, which appeared in issue 10, May 13, 2003, of Proc. Natl. Acad. Sci. USA (100, 6069–6074; First Published April 29, 2003; 10.1073 pnas.1031521100), due to(More)
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