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OBJECTIVE Linear atrial radiofrequency lesions have been used effectively for the treatment of atrial fibrillation. In most cases an endocardial approach has been suggested. A method for epicardial placement of lesions would reduce the complexity of these procedures. We compared lesions created in ovine hearts in vivo using irrigated bipolar or unipolar(More)
OBJECTIVE To perform a systematic review of randomized controlled trials (RCTs) on catheter ablation for atrial fibrillation (AF). BACKGROUND Radiofrequency catheter (RF)-ablation around pulmonary vein ostia and in left atrium may reduce or prevent recurrence of AF, as documented in observational studies and registry reports; however, few RCTs are(More)
Hypothermia-rewarming of the heart results in contractile dysfunction under in vitro as well as in vivo conditions. Increase in reactive oxygen species (ROS), lipid peroxidation and calcium overload are proposed mechanisms. In the first protocol of this study, the effect of putative phospholipase and calcium channel modulator mepacrine during deep(More)
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