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Tumor related contralateral motor deficits complicate preoperative functional magnetic resonance imaging (fMRI). In plegic patients the localization of the sensorimotor cortex is often impossible. In this context we developed a clinical fMRI protocol dedicated to patients with motor deficits using the unaffected ipsilateral hand. Based on the hypothesis(More)
The clinical application of functional magnetic resonance imaging (fMRI) requires time-saving protocols insensitive to artifacts that provide robust localization and important information on brain function. A fully automated, pneumatically driven tactile stimulation is presented, that reproducibly localizes postcentral lip, finger and toe representations in(More)
On the basis of well documented biochemical and pharmacological data about the influence of drug mediated enzyme induction on the biotransformation of natural and synthetic sex steroids, practical consequences for hormonal steroid contraception are described and discussed. Clinical reports dealing with this problem are still sparse. The clinical symptoms of(More)
Whereas some arguments can be advanced suggesting that the life expectancy in east Germany should have declined directly after the fall of the Berlin Wall in 1989, other arguments suggest an increase. The aim of this study was to identify the actual developments and to explain the findings. Census data and mortality statistics from East and West Germany(More)
Caffeine is mainly metabolized by 3-methylcholanthreneinducible cytochrome P-450, whereas metamizol (Analgin) is probably mainly metabolized by the phenobarbital inducible cytochrome P-450 family. Therefore the elimination of caffeine from serum and the elimination of the main metabolites of metamizol in urine reflect the activity of these two cytochrome(More)
Studies were conducted into the effects of intragestational hypotension and Broca's index of mothers on the birth weights of newborns, with reference being to intensive pregnancy care documentation filed for the years 1977 through 1979 at the Gynaecological Hospital of Friedrich-Schiller-Universität Jena, GDR. The low birth weights quoted in literature were(More)
The purpose of this study was to generate quadruple fluorescent protein (QFP) transgenic mice as a source for QFP-expressing neural stem and progenitor cells (NSCs/NPCs) that could be utilized as a tool for transplantation research. When undifferentiated, these NSCs only express cyan fluorescent protein (CFP); however, upon neuronal differentiation, the(More)