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OBJECTIVE To develop a disease-specific QOL instrument (QOLRAD) addressing patient concerns in gastroesophageal reflux disease (GERD) and dyspepsia. Patients. 759 male (45%) and female (55%) patients with a mean age of 48.4 years (sd 15.2) were used in the psychometric evaluation. MAIN OUTCOME MEASURES A pilot version of QOLRAD, the Gastrointestinal(More)
BACKGROUND The symptoms and signs of small intestinal bacterial overgrowth (SIBO) are often identical to a variety of diseases and can lead to diagnostic confusion. AIMS To review the diagnostic options for SIBO and present new investigative options for the condition. METHODS A literature search was performed on MEDLINE, EMBASE and Web of Science for(More)
OBJECTIVE To determine whether a "test for Helicobacter pylori and treat" strategy improves symptoms in patients with uninvestigated dyspepsia in primary care. DESIGN Randomised placebo controlled trial. SETTING 36 family practices in Canada. PARTICIPANTS 294 patients positive for H pylori ((13)C- urea breath test) with symptoms of dyspepsia of at(More)
BACKGROUND Adult Helicobacter pylori-positive patients by 13C-urea breath test with uninvestigated dyspepsia symptoms were randomized to 1-week eradication treatment with omeprazole, metronidazole and clarithromycin (OMC) vs. omeprazole and placebo antimicrobials (OPP) in the Canadian Adult Dyspepsia Empiric Treatment-H. pylori-positive (CADET-Hp) study. (More)
Objective To determine whether a " test for Helicobacter pylori and treat " strategy improves symptoms in patients with uninvestigated dyspepsia in primary care. Design Randomised placebo controlled trial. Setting 36 family practices in Canada. Participants 294 patients positive for H pylori (13 C-urea breath test) with symptoms of dyspepsia of at least(More)
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