Eike Krause

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BACKGROUND MYH9-related disease (MYH9-RD) is a rare syndromic disorder deriving from mutations in MYH9, the gene for the heavy chain of non-muscle myosin IIA. Patients present with congenital thrombocytopenia and giant platelets and have a variable risk of developing sensorineural deafness, kidney damage, presenile cataract, and liver abnormalities. Almost(More)
OBJECTIVE To study the correlation between the degree of endolymphatic hydrops as detected in vivo by magnetic resonance (MR) imaging and the auditory and vestibular function in patients with definite Ménière's disease. STUDY DESIGN Prospective observational study. SETTING Tertiary referral center for balance disorders. SUBJECTS AND METHODS In this(More)
Our objective is to determine whether the degree of endolymphatic hydrops as it is detected in vivo in patients with definite Meniere's disease correlates with audiovestibular function. In this prospective study, 37 patients with definite Meniere's disease according to AAO-HNS criteria were included. Intratympanic contrast enhanced temporal bone MRI was(More)
OBJECTIVE To visualize the progression of endolymphatic hydrops in a patient with Ménière's disease. PATIENT AND METHODS A 53-year-old patient with definite Ménière's disease underwent locally enhanced inner ear magnetic resonance imaging (LEIM) for visualizing endolymphatic hydrops. Two years later, a second magnetic resonance imaging was performed for(More)
INTRODUCTION Canal paresis of the horizontal semicircular canal in Ménière's disease is a frequent finding. Endolymphatic hydrops is the single most characteristic morphologic finding in Ménière's disease. However, the relationship between endolymphatic hydrops and canal paresis is still not elucidated. METHODS We used magnetic resonance imaging to(More)
Palatal myoclonus (PM) is a rare neurotological disorder but is being reported with increasing frequency. Two forms, symptomatic and essential PM, have been identified as separate clinical entities and probably also have separate etiologies. In essential PM, brain imaging is unremarkable and a clicking noise caused by peritubal muscle contractions and often(More)
BACKGROUND Due to increasing drug resistance, artemisinin-based combination chemotherapy (ACT) has become the first-line treatment of falciparum malaria in many endemic countries. However, irreversible ototoxicity associated with artemether/lumefantrine (AL) has been reported recently and suggested to be a serious limitation in the use of ACT. The aim of(More)
OBJECTIVE To obtain clinical and audiometric findings in traumatic tympanic membrane perforations from a typical patient collective in a Western industrial nation because the appropriate data have an important relevance in medicolegal questions. STUDY DESIGN Retrospective data collection. SETTING Germany's largest university clinic for(More)
Loud low-frequency sounds can induce temporary oscillatory changes in cochlear sensitivity, which have been termed the 'bounce' phenomenon. The origin of these sensitivity changes has been attributed to slow fluctuations in cochlear homeostasis, causing changes in the operating points of the outer hair cell mechano-electrical and electro-mechanical(More)
OBJECTIVE Investigate whether the cochleostomy is a possible port of entry for pneumolabyrinth and a resulting vertigo in patients provided with a cochlear implant. STUDY DESIGN Retrospective case review. SETTING Ludwig-Maximilians University of Munich, Hospital Grosshadern. PATIENT 62-year-old patient who underwent implantation of a HiFocus II(More)