Eike Dieter Schomburg

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 The generation of locomotor-like spinal rhythms has been proposed to involve two neural centres with mutual reciprocal inhibition (Graham Brown’s ”half-centre” hypothesis). Much later a particular set of segmental flexor reflex pathways were described as being organized in accordance with this half-centre hypothesis. As these pathways became operative(More)
To understand the pathomechanisms of spinal cord injuries will be a prerequisite to develop efficient therapies. By investigating acute lesions of spinal cord white matter in anesthetized mice with fluorescently labeled microglia and axons using in vivo two-photon laser-scanning microscopy (2P-LSM), we identified the messenger nitric oxide (NO) as a(More)
The interneuronally mediated reflex actions evoked by electrical stimulation of group II muscle afferents in low spinal cats have been reinvestigated with intracellular recording with motoneurones to knee flexors and ankle extensors. The results of Eccles and Lundberg (1959) have been confirmed and extended. There was wide convergence from flexors and(More)
The LDL receptor-related protein 1 (LRP1) is a multifunctional cell surface receptor that is highly expressed on neurons. Neuronal LRP1 in vitro can mediate ligand endocytosis, as well as modulate signal transduction processes. However, little is known about its role in the intact nervous system. Here, we report that mice that lack LRP1 selectively in(More)
In high spinal paralysed cats electromyograms were recorded from nerves supplying lumbar back muscles (longissimus dorsi) and abdominal muscles (obliquus abdominis externus) during fictive locomotion induced by I.V. injection of nialamide and L-DOPA. Activity in nerves to hind-limb muscles was also recorded. During periods of stable 'locomotor' activity in(More)
For a large number of vertebrate species it is now indisputable that spinal networks have the capability of generating the basic locomotor rhythm. However, because of technical difficulties, the rate of progress in defining the intrinsic properties of mammalian locomotor rhythm generators has been slow in comparison to that made in the study of such(More)
In spinal and decerebrate cats fine muscle afferents (group III and IV) were selectively activated by intra-arterial injection of bradykinin and KCl into the gastrocnemius-soleus muscle. By this method the synaptic responses induced in lumbar alpha-motoneurones by fine muscle afferents could be examined without interference of effects from large afferents.(More)
The contribution of group III and IV muscle afferents to multisensorial segmental reflex pathways was investigated by testing for spatial facilitation between these afferents and non-nociceptive segmental afferents from skin, muscles and joints on postsynaptic potentials (PSPs) in alpha-motoneurones recorded in anaemically decapitated high spinal cats.(More)
1. Intracellular recording from motoneurones to hind limb muscles in the cat was used to investigate the effect of volleys in the posterior nerve to the knee joint on motoneurones and on transmission from Ib afferents. 2. Volleys in the joint nerve facilitate transmission in disynaptic and trisynaptic inhibitory and excitatory reflex pathways from Ib(More)