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Time dependence of cyclic tensile strain on collagen production in tendon fascicles.
Mechanical loading is a regulator of tissue metabolism in tendon, which may lead to alterations in structural and mechanical properties via mechanotransduction processes. The present studyExpand
Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain
Tenocytes are known to be mechanoresponsive and the present study tests the hypothesis that distinct mechanical stimulation regimes, associated with the short-term and extended application of cyclicExpand
Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substrates.
Actin cytoskeletons, aggregated with myosin II, generate intracellular cytoskeletal tension, which is induced to cell attaching substrate as cell traction forces. It is thought that cytoskeletalExpand
Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading
Gap junction communication is an essential component in the mechanosensitive response of tenocytes. However, little is known about direct mechanoregulation of gap junction turnover and permeability.Expand
Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro.
Mechanical stimulus is a regulator of tenocyte metabolism. The present study investigated temporal regulation of the expression of selected genes by tenocytes in isolated fascicles subjected toExpand
A new experimental system for simultaneous application of cyclic tensile strain and fluid shear stress to tenocytes in vitro
Tenocyte mechanotransduction has been of great interest to researchers in tendon mechanobiology and biomechanics. In vivo, tenocytes are subjected to tensile strain and fluid shear stress, but mostExpand
Mechano-regulation of gap junction communications between tendon cells is dependent on the magnitude of tensile strain.
Large magnitudes of mechanical strain applied to tendon cells induce catabolic and inflammatory responses, whereas a moderate level of strain promotes anabolism. Gap junction intercellularExpand
Effects of stress shielding and subsequent restressing on mechanical properties of regenerated and residual tissues in rabbit patellar tendon after resection of its central one-third.
Central third of patellar tendon (PT) is used as an autograft for anterior cruciate ligament (ACL) reconstruction. Previous studies investigated temporal changes in material properties of healingExpand
Enhanced gap junction intercellular communication inhibits catabolic and pro-inflammatory responses in tenocytes against heat stress
Elevation of tendon core temperature during severe activity is well known. However, its effects on tenocyte function have not been studied in detail. The present study tested a hypothesis that heatExpand
Tenocyte anabolic and catabolic response to elevation in intracellular tension
The present study examined expressions of type I collagen and MMP-1 mRNA of bovine tenocytes in response to elevation in intracellular tension/traction forces induced by either mechanical or chemicalExpand
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