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Neutrophil infiltration mediated by TNF-alpha is associated with various types of gastric injury, whereas PGs play a crucial role in gastric defense. We examined roles of two isoforms of cyclooxygenase (COX) and PGE2 in Helicobacter pylori-induced gastritis in mice. Mice infected with H. pylori were given selective COX-1 inhibitor SC-560 (10 mg/kg),(More)
The effects of diclofenac (Dic), an acetic acid derivative-type nonsteroidal anti-inflammatory drug, were examined on the function of transient receptor potential (TRP) melastatin (TRPM) 3 (TRPM3) in human embryonic kidney 293 cell-line (HEK293) cells with recombinant human TRPM3 isoforms (TRPM31325, TRPM3-3, TRPM3-9, and TRPM3-S) and in a neuroblastoma(More)
Neutrophil infiltration mediated by tumor necrosis factor-(TNF-) is associated with various types of gastric injury, whereas prostaglandins (PGs) play a crucial role in gastric defense. We examined the roles of two isoforms of cyclooxygenase (COX) and PGE 2 in Helicobacter pylori (H. pylori)-induced gastritis in mice. Mice infected with H. pylori were given(More)
OVERVIEW: We have developed signaling systems to increase the transportation capacity and ease rush-hour traffic in metropolitan areas. This is achieved by using an on-board controller that generates a parabolic braking pattern according to the limit of movement authority (LMA) transmitted from digital field controllers. One system is called " the digital(More)
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