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When sustained-release adhesive and non-adhesive microspheres which release the same drugs at similar rates are administered orally, drug absorption after administration of adhesive microspheres should, if the gastrointestinal residence of adhesive microspheres is prolonged as a result of mucoadhesion, be higher than that after administration of(More)
[3H]Water and [14C]inulin were injected into perfused rabbit muscle with or without hyaluronidase (300 units/ml) and their absorption into venous effluent from muscle was determined. Hyaluronidase accelerated the absorption of both compounds but the enhancement of [14C]inulin was much larger than that for [3H]water. The pharmacokinetic analysis of venous(More)
In a rabbit hind leg perfusion experiment, the absorption of radiolabeled water and carbohydrates of various molecular sizes from muscle was analyzed using a physiological diffusion model and, also, by statistical moment analysis. The model takes into account diffusion in the interstitial space, transcap-illary movement, and removal by the blood circulation(More)
Application of the statistical moment analysis to the local organ perfusion system leads moment parameters (moments) from the venous outflow concentration-time curve (dilution curve) of drug after its intraarterial bolus injection. By introducing the chromatographic concept and the network theory, we had defined the disposition parameters such as steady(More)
Drug absorption from muscle has been examined using the rabbit hind leg, isolated by cannulating the femoral artery and vein, and perfused with or without bovine serum albumin (BSA) using a single-pass technique. A model compound, [14C]sucrose, was injected into the musculus gastrocnemius, and its appearance in the venous outflow was monitored and(More)
Pharmacokinetics and pharmacodynamics of novel oral sustained-release granules based on swelling polymer incorporation layer system (SPILA granules) containing morphine hydrochloride was evaluated. SPILA granules were designed to release morphine faster in neutral environment than in acidic one to keep higher plasma levels over a protracted period,(More)
A new oral sustained-release (SR) drug delivery system utilizing pH-dependent swelling of carboxyvinyl polymer (CP) has been proposed. This swelling polymer incorporation layer system, referred to as SPILA system, consists of core granules coated with a mixture of CP, water insoluble polymer, and water-soluble polymer (WP). Release profiles of metoprolol(More)
The effect of enzyme induction on the hepatobiliary transport of phenol red (PR) in rats was investigated by application of a new analytical system to determine local drug disposition based on statistical moment theory (T. Kakutani et al., J. Pharmacokin. Bio-pharm. 13:609–631, 1985). Employing the moment parameters obtained from the time courses of plasma(More)
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