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Leptin deficiency suppresses progression of atherosclerosis in apoE-deficient mice.
Both experimental and epidemiological studies suggest that leptin is one of the molecules responsible for accelerated atherosclerosis in obese humans. To confirm the notion, we studied whether leptinExpand
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Genomic Analysis of Two Siblings with 17.ALPHA.-Hydroxylase Deficiency and Hypertension.
17α-hydroxylase/17, 20-lyase deficiency is an autosomal recessive disorder, which causes mineralcorticoid hypertension. Here we report two Japanese siblings, male and female, affected by 17α-Expand
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Blood biochemical changes in mice after administration of a mixture of three anesthetic agents
Currently, from the viewpoint of animal welfare, anesthesia or analgesia is required during experimental procedures in animals that are likely to cause pain. A part of these anesthetics have beenExpand
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A Selective NFκB Inhibitor, DHMEQ, Reduced Atherosclerosis in ApoE-deficient mice
Background and Purpose: Atherosclerosis is a chronic inflammatory process, and anti-inflammatory agents potentially inhibit the development of atherosclerosis. We tested whether a novel NFkBExpand
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Insulin Signaling in Arteries Prevents Smooth Muscle Apoptosis
Objective—Insulin is an antiapoptotic factor of cultured vascular cells, but it is not clear whether it also exerts antiapoptotic effects on vascular cells in vivo. We studied insulin receptorExpand
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Hepatocellular carcinoma in a mouse model fed a choline‐deficient, L‐amino acid‐defined, high‐fat diet
Hepatocellular carcinoma (HCC) is a common cancer worldwide and represents the outcome of the natural history of chronic liver disease. The growing rates of HCC may be partially attributable toExpand
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Analyses of mutation and loss of heterozygosity of coding sequences of the entire transforming growth factor beta type II receptor gene in sporadic human gastric cancer.
Mutations in the transforming growth factor beta type II receptor (TGFbetaRII) gene have been detected in several human cancer types exhibiting microsatellite instability. Using intron primersExpand
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Short communication: A positive relationship between the first ovulation postpartum and the increasing ratio of milk yield in the first part of lactation in dairy cows.
The aim of the present study was to examine the relationship between characteristics of the lactation curve, on the basis of daily milk yield, and ovulation within 3 wk postpartum as an indicator ofExpand
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