Eiichi Nakamura

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The efficient treatment of lung diseases requires lung-selective delivery of agents to the lung. However, lung-selective delivery is difficult because the accumulation of micrometer-sized carriers in the lung often induces inflammation and embolization-related toxicity. Here we demonstrate a lung-selective delivery system of small interfering RNA (siRNA) by(More)
Polar liquid crystalline materials can be used in optical and electronic applications, and recent interest has turned to formation strategies that exploit the shape of polar molecules and their interactions to direct molecular alignment. For example, banana-shaped molecules align their molecular bent within smectic layers, whereas conical molecules should(More)
The low solubility of fullerenes in aqueous solution limits their applications in biology. By appropriate substitution, the fullerenes can be transformed into stabilized anions that are water soluble and can form large aggregated structures. A laser light scattering study of the association behavior of the potassium salt of pentaphenyl fullerene (Ph5C60K)(More)
High-resolution transmission electron microscopy revealed nearly atomically precise images of stepping conformational change and translational motion of single hydrocarbon molecules confined in carbon nanotubes. One or two C12 or C22 alkyl chains were tethered to a carborane end group and then embedded in the nanotubes. Images of the hydrocarbon chains(More)
The idea of " bucky ferrocene " intrigues chemists owing to its aesthetic beauty and to its polarized, extended conjugated system, but the idea has remained hypothetical. The synthesis of close analogs of Fe(C 60 Me 5)Cp and Fe(C 70 Me 3)Cp was achieved in two steps from [60] and [70]fullerenes, relying on an oxidative C–H bond activation starting with an(More)
Thin film organic lasers represent a new generation of inexpensive, mechanically flexible devices for spectroscopy, optical communications and sensing. For this purpose, it is desired to develop highly efficient, stable, wavelength-tunable and solution-processable organic laser materials. Here we report that carbon-bridged oligo(p-phenylenevinylene)s serve(More)
Random telegraphic noises with a preferential jump height around 0.018G(0) were observed in the conductance traces of the Au-pentacene-Au junctions. The distribution of the plateau lifetime obeyed an exponential distribution, but the decay constants were independent of the height of the adjacent conductance jumps or the measurement temperature. This result,(More)
Systematic evaluation of method and basis set on the structure and energetics of organocuprate(I) and organocopper(III) species has been carried out. Various structures of organocuprate(I) and organocuprate(III) complexes were optimized with the HF, MP2, and B3LYP methods, and compared with the structures determined by X-ray crystallography (i.e.,(More)
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